Chemical enhancer induced changes in the mechanisms of transdermal delivery of zinc oxide nanoparticles

Tsung Rong Kuo; Chung Long Wu; Chih Ting Hsu; Wen Lo; Shu Jen Chiang; Sung Jan Lin; Chen Yuan Dong; Chia Chun Chen

doi:10.1016/j.biomaterials.2009.02.003

Chemical enhancer induced changes in the mechanisms of transdermal delivery of zinc oxide nanoparticles

Tsung Rong Kuo, Chung Long Wu, Chih Ting Hsu, Wen Lo, Shu Jen Chiang, Sung Jan Lin, Chen Yuan Dong, Chia Chun Chen

Research output: Contribution to journal › Article › peer-review

98 Citations (Scopus)

Abstract

The overlapping wavelength of photoluminescence (PL) of zinc oxide nanoparticles (ZnO NPs) and autofluorescence (AF) from the stratum corneum (SC) has for a long time held back researchers from investigating the chemically enhanced penetration pathways of ZnO NPs into the SC lipids. However, the non-linear polarization effect of second harmonic generation (SHG) may be used for ZnO NPs to be distinguished from the AF of the SC. This study combined the SHG of ZnO NPs and the AF of the SC to image the transdermal delivery of ZnO NPs under the chemical enhancer conditions of oleic acid (OA), ethanol (EtOH) and oleic acid-ethanol (OA-EtOH). In addition to qualitative imaging, the microtransport properties of ZnO NPs were quantified to give the enhancements of the vehicle-to-skin partition coefficient (K), the SHG intensity gradient (G) and the effective diffusion path length (L). The results showed that OA, EtOH and OA-EtOH were all capable of enhancing the transdermal delivery of ZnO NPs by increasing the intercellular lipid fluidity or extracting lipids from the SC.

Original language	English
Pages (from-to)	3002-3008
Number of pages	7
Journal	Biomaterials
Volume	30
Issue number	16
DOIs	https://doi.org/10.1016/j.biomaterials.2009.02.003
Publication status	Published - Jun 2009
Externally published	Yes

Keywords

Chemical enhancer
Second harmonic generation
Transdermal
Two-photon microscopy
ZnO nanoparticles

ASJC Scopus subject areas

Biophysics
Bioengineering
Ceramics and Composites
Biomaterials
Mechanics of Materials

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10.1016/j.biomaterials.2009.02.003

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@article{809ecead803640c58532d7ef311cb2b4,

title = "Chemical enhancer induced changes in the mechanisms of transdermal delivery of zinc oxide nanoparticles",

abstract = "The overlapping wavelength of photoluminescence (PL) of zinc oxide nanoparticles (ZnO NPs) and autofluorescence (AF) from the stratum corneum (SC) has for a long time held back researchers from investigating the chemically enhanced penetration pathways of ZnO NPs into the SC lipids. However, the non-linear polarization effect of second harmonic generation (SHG) may be used for ZnO NPs to be distinguished from the AF of the SC. This study combined the SHG of ZnO NPs and the AF of the SC to image the transdermal delivery of ZnO NPs under the chemical enhancer conditions of oleic acid (OA), ethanol (EtOH) and oleic acid-ethanol (OA-EtOH). In addition to qualitative imaging, the microtransport properties of ZnO NPs were quantified to give the enhancements of the vehicle-to-skin partition coefficient (K), the SHG intensity gradient (G) and the effective diffusion path length (L). The results showed that OA, EtOH and OA-EtOH were all capable of enhancing the transdermal delivery of ZnO NPs by increasing the intercellular lipid fluidity or extracting lipids from the SC.",

keywords = "Chemical enhancer, Second harmonic generation, Transdermal, Two-photon microscopy, ZnO nanoparticles",

author = "Kuo, {Tsung Rong} and Wu, {Chung Long} and Hsu, {Chih Ting} and Wen Lo and Chiang, {Shu Jen} and Lin, {Sung Jan} and Dong, {Chen Yuan} and Chen, {Chia Chun}",

note = "Funding Information: This study was financially supported by the National Science Council (NSC), Taiwan (NSC-96-3112-B-002-025, NSC-95-3112-B-002-019, NSC-94-3112-B-002015Y, and NSC-96-2120-M003-001), and National Taiwan University Hospital (975-842). The two-photon experiments and data analysis were performed at the Optical Molecular Imaging Microscopy Core Facility (A5) of the National Research Program for Genomic Medicine of NSC in Taiwan. ",

year = "2009",

month = jun,

doi = "10.1016/j.biomaterials.2009.02.003",

language = "English",

volume = "30",

pages = "3002--3008",

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issn = "0142-9612",

publisher = "Elsevier Science Ltd",

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T1 - Chemical enhancer induced changes in the mechanisms of transdermal delivery of zinc oxide nanoparticles

AU - Kuo, Tsung Rong

AU - Wu, Chung Long

AU - Hsu, Chih Ting

AU - Lo, Wen

AU - Chiang, Shu Jen

AU - Lin, Sung Jan

AU - Dong, Chen Yuan

AU - Chen, Chia Chun

N1 - Funding Information: This study was financially supported by the National Science Council (NSC), Taiwan (NSC-96-3112-B-002-025, NSC-95-3112-B-002-019, NSC-94-3112-B-002015Y, and NSC-96-2120-M003-001), and National Taiwan University Hospital (975-842). The two-photon experiments and data analysis were performed at the Optical Molecular Imaging Microscopy Core Facility (A5) of the National Research Program for Genomic Medicine of NSC in Taiwan.

PY - 2009/6

Y1 - 2009/6

N2 - The overlapping wavelength of photoluminescence (PL) of zinc oxide nanoparticles (ZnO NPs) and autofluorescence (AF) from the stratum corneum (SC) has for a long time held back researchers from investigating the chemically enhanced penetration pathways of ZnO NPs into the SC lipids. However, the non-linear polarization effect of second harmonic generation (SHG) may be used for ZnO NPs to be distinguished from the AF of the SC. This study combined the SHG of ZnO NPs and the AF of the SC to image the transdermal delivery of ZnO NPs under the chemical enhancer conditions of oleic acid (OA), ethanol (EtOH) and oleic acid-ethanol (OA-EtOH). In addition to qualitative imaging, the microtransport properties of ZnO NPs were quantified to give the enhancements of the vehicle-to-skin partition coefficient (K), the SHG intensity gradient (G) and the effective diffusion path length (L). The results showed that OA, EtOH and OA-EtOH were all capable of enhancing the transdermal delivery of ZnO NPs by increasing the intercellular lipid fluidity or extracting lipids from the SC.

AB - The overlapping wavelength of photoluminescence (PL) of zinc oxide nanoparticles (ZnO NPs) and autofluorescence (AF) from the stratum corneum (SC) has for a long time held back researchers from investigating the chemically enhanced penetration pathways of ZnO NPs into the SC lipids. However, the non-linear polarization effect of second harmonic generation (SHG) may be used for ZnO NPs to be distinguished from the AF of the SC. This study combined the SHG of ZnO NPs and the AF of the SC to image the transdermal delivery of ZnO NPs under the chemical enhancer conditions of oleic acid (OA), ethanol (EtOH) and oleic acid-ethanol (OA-EtOH). In addition to qualitative imaging, the microtransport properties of ZnO NPs were quantified to give the enhancements of the vehicle-to-skin partition coefficient (K), the SHG intensity gradient (G) and the effective diffusion path length (L). The results showed that OA, EtOH and OA-EtOH were all capable of enhancing the transdermal delivery of ZnO NPs by increasing the intercellular lipid fluidity or extracting lipids from the SC.

KW - Chemical enhancer

KW - Second harmonic generation

KW - Transdermal

KW - Two-photon microscopy

KW - ZnO nanoparticles

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SN - 0142-9612

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EP - 3008

JO - Biomaterials

JF - Biomaterials

IS - 16

ER -

Chemical enhancer induced changes in the mechanisms of transdermal delivery of zinc oxide nanoparticles

Abstract

Keywords

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