TY - JOUR
T1 - Chemical Constituents of the Endophytic Fungus Phomopsis asparagi Isolated from the Plant Peperomia sui
AU - Chang, Hsun Shuo
AU - Peng, Chien Jou
AU - Cheng, Ming Jen
AU - Wu, Ho Cheng
AU - Chan, Hing Yuen
AU - Hsieh, Sung Yuan
AU - Yuan, Gwo Fang
AU - Chen, Ih Sheng
N1 - Funding Information:
This investigation was supported by a Grant from the Ministry of Economic Affairs of the Republic of China.
Publisher Copyright:
© 2018, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2018/5/1
Y1 - 2018/5/1
N2 - Investigation of the ethyl acetate-soluble layer from the liquid fermentation of Phomopsis asparagi, an endophytic fungus isolated from the Taiwanese endemic plant of Peperomia sui T.T. Lin & S.Y. Lu, led to the isolation of a new cytochalasin, phomocytochalasin A (1), and one benzenoid, phomoaspardiol (2), which was isolated from nature for the first time, along with eight known compounds including two cytochalasins, four benzenoids, one chromone, and one steroid. The structures of the isolates were established by spectroscopic methods, including UV, IR, HR-ESI-MS, and extensive 1D and 2D NMR techniques, as well as by comparison with literature reports. Among the isolates, cytochalasin J showed androgen receptor (AR) antagonism with the IC50 value of 6.20 μM.
AB - Investigation of the ethyl acetate-soluble layer from the liquid fermentation of Phomopsis asparagi, an endophytic fungus isolated from the Taiwanese endemic plant of Peperomia sui T.T. Lin & S.Y. Lu, led to the isolation of a new cytochalasin, phomocytochalasin A (1), and one benzenoid, phomoaspardiol (2), which was isolated from nature for the first time, along with eight known compounds including two cytochalasins, four benzenoids, one chromone, and one steroid. The structures of the isolates were established by spectroscopic methods, including UV, IR, HR-ESI-MS, and extensive 1D and 2D NMR techniques, as well as by comparison with literature reports. Among the isolates, cytochalasin J showed androgen receptor (AR) antagonism with the IC50 value of 6.20 μM.
KW - androgen antagonism
KW - benzenoid
KW - cytochalasin
KW - Peperomia sui
KW - Phomopsis asparagi
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U2 - 10.1007/s10600-018-2390-3
DO - 10.1007/s10600-018-2390-3
M3 - Article
AN - SCOPUS:85048061054
SN - 0009-3130
VL - 54
SP - 504
EP - 508
JO - Chemistry of Natural Compounds
JF - Chemistry of Natural Compounds
IS - 3
ER -