Chemical constituents from the medicinal herb-derived fungus Chaetomium globosum Km1226

Chia Hao Chang, George Hsiao, Shih Wei Wang, Juei Yu Yen, Shu Jung Huang, Wei Chiung Chi, Tzong Huei Lee

Research output: Contribution to journalArticlepeer-review


Background: Endophytic fungi have proven to be a rich source of novel natural products with a wide-array of biological activities and higher levels of structural diversity. Results: Chemical investigation on the liquid- and solid-state fermented products of Chaetomium globosum Km1226 isolated from the littoral medicinal herb Atriplex maximowicziana Makino resulted in the isolation of compounds 1–14. Their structures were determined by spectroscopic analysis as three previously undescribed C13-polyketides, namely aureonitol C (1), mollipilins G (2), and H (3), along with eleven known compounds 4–14. Among these, mollipilin A (5) exhibited significant nitric oxide production inhibitory activity in LPS-induced BV-2 microglial cells with an IC50 value of 0.7 ± 0.1 µM, and chaetoglobosin D (10) displayed potent anti-angiogenesis property in human endothelial progenitor cells (EPCs) with an IC50 value of 0.8 ± 0.3 µM. Conclusions: Three previously unreported compounds 1–3 were isolated and identified. Mollipilin A (5) and chaetoglobosin D (10) could possibly be developed as anti-inflammatory and anti-angiogenic lead drugs, respectively.

Original languageEnglish
Article number34
JournalBotanical Studies
Issue number1
Publication statusPublished - Dec 2023


  • Anti-angiogenesis
  • Anti-inflammation
  • Aureonitol
  • Chaetomium globosum
  • Mollipilin
  • Polyketide

ASJC Scopus subject areas

  • Plant Science


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