Chemical constituents from fermented broth and mycelium of the basidiomycete Lacrymaria velutina

Yu Ming Ju; Guei Jane Wang; Chun Yao Chen; Ya Jing Tsau; Chang Hung Chou; Zong-Huei Li

Chemical constituents from fermented broth and mycelium of the basidiomycete Lacrymaria velutina

Yu Ming Ju, Guei Jane Wang, Chun Yao Chen, Ya Jing Tsau, Chang Hung Chou, Zong-Huei Li

Graduate Institute of Pharmacognosy

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Lacrymarone (1), a novel diterpenoid, together with seven known compounds 2-8 were isolated from the fermented broth and mycelium of Lacrymaria velutina, an edible fungus collected in Taiwan. The structures of 1-8 were elucidated by analyzing their spectroscopic data. Further biological tests revealed that the co-crystal of 7 and 8 exhibited a moderate inducible nitric oxide synthase (iNOS) inhibitory activity, and with an IC₅₀ value of 59.54 ± 3.74 μM.

Original language	English
Pages (from-to)	311-315
Number of pages	5
Journal	Botanical Studies
Volume	51
Issue number	3
Publication status	Published - Jul 2010

Keywords

Basidiomycete
Inducible nitric oxide synthase (iNOS)
Lacrymaria velutina
Lacrymarone

ASJC Scopus subject areas

Plant Science

Cite this

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title = "Chemical constituents from fermented broth and mycelium of the basidiomycete Lacrymaria velutina",

abstract = "Lacrymarone (1), a novel diterpenoid, together with seven known compounds 2-8 were isolated from the fermented broth and mycelium of Lacrymaria velutina, an edible fungus collected in Taiwan. The structures of 1-8 were elucidated by analyzing their spectroscopic data. Further biological tests revealed that the co-crystal of 7 and 8 exhibited a moderate inducible nitric oxide synthase (iNOS) inhibitory activity, and with an IC50 value of 59.54 ± 3.74 μM.",

keywords = "Basidiomycete, Inducible nitric oxide synthase (iNOS), Lacrymaria velutina, Lacrymarone",

author = "Ju, {Yu Ming} and Wang, {Guei Jane} and Chen, {Chun Yao} and Tsau, {Ya Jing} and Chou, {Chang Hung} and Zong-Huei Li",

year = "2010",

month = jul,

language = "English",

volume = "51",

pages = "311--315",

journal = "Botanical Studies",

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T1 - Chemical constituents from fermented broth and mycelium of the basidiomycete Lacrymaria velutina

AU - Ju, Yu Ming

AU - Wang, Guei Jane

AU - Chen, Chun Yao

AU - Tsau, Ya Jing

AU - Chou, Chang Hung

AU - Li, Zong-Huei

PY - 2010/7

Y1 - 2010/7

N2 - Lacrymarone (1), a novel diterpenoid, together with seven known compounds 2-8 were isolated from the fermented broth and mycelium of Lacrymaria velutina, an edible fungus collected in Taiwan. The structures of 1-8 were elucidated by analyzing their spectroscopic data. Further biological tests revealed that the co-crystal of 7 and 8 exhibited a moderate inducible nitric oxide synthase (iNOS) inhibitory activity, and with an IC50 value of 59.54 ± 3.74 μM.

AB - Lacrymarone (1), a novel diterpenoid, together with seven known compounds 2-8 were isolated from the fermented broth and mycelium of Lacrymaria velutina, an edible fungus collected in Taiwan. The structures of 1-8 were elucidated by analyzing their spectroscopic data. Further biological tests revealed that the co-crystal of 7 and 8 exhibited a moderate inducible nitric oxide synthase (iNOS) inhibitory activity, and with an IC50 value of 59.54 ± 3.74 μM.

KW - Basidiomycete

KW - Inducible nitric oxide synthase (iNOS)

KW - Lacrymaria velutina

KW - Lacrymarone

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SN - 1817-406X

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JO - Botanical Studies

JF - Botanical Studies

IS - 3

ER -

Chemical constituents from fermented broth and mycelium of the basidiomycete Lacrymaria velutina

Abstract

Keywords

ASJC Scopus subject areas

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