Characterizations of doxorubicin-loaded PEGylated magnetic liposomes for cancer cells therapy

Andri Hardiansyah; Fredina Destyorini; Yuyun Irmawati; Ming Chien Yang; Chi Ming Liu; Elsy Rahimi Chaldun; Ming Chi Yung; Ting Yu Liu

doi:10.1007/s10965-019-1964-5

Characterizations of doxorubicin-loaded PEGylated magnetic liposomes for cancer cells therapy

Andri Hardiansyah, Fredina Destyorini, Yuyun Irmawati, Ming Chien Yang, Chi Ming Liu, Elsy Rahimi Chaldun, Ming Chi Yung, Ting Yu Liu

Taipei Medical University Hospital

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Magnetic-guided drug delivery system for cancer treatment can be realized by elaborating drug and magnetic nanoparticles (MNP) on the liposomes through the assistance of magnetic field exposure. Here, we prepared PEGylated liposomes (liposomes with poly-(ethylene glycol) (PEG) modification) to encapsulate doxorubicin (DOX) and MNP, termed as DOX-loaded PEGylated magnetic liposomes. We show that the DOX-loaded PEGylated magnetic liposomes exhibits spherical morphology with diameter about 100 nm, dispersed homogeneously in aqueous system and generate inductive heating from 37^o to 56 °C by means of high-frequency magnetic field (HFMF) exposure. Moreover, DOX could kill HeLa cells due to DOX releasing indicating the DOX cytotoxicity to the HeLa cells as a function of DOX concentration. In conclusion, these liposomes could combine the function of DOX and MNP, opening a route as a drug carrier platform to enhance the therapeutic efficacy of chemotherapeutic drug and it could be integrated with the development of magnetic-guided drug delivery.

Original language	English
Article number	282
Journal	Journal of Polymer Research
Volume	26
Issue number	12
DOIs	https://doi.org/10.1007/s10965-019-1964-5
Publication status	Published - Dec 1 2019

Keywords

Cytocompatibility
Doxorubicin
Liposomes
Magnetic nanoparticles
Poly-(ethylene glycol)

ASJC Scopus subject areas

Polymers and Plastics
Organic Chemistry
Materials Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10965-019-1964-5

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title = "Characterizations of doxorubicin-loaded PEGylated magnetic liposomes for cancer cells therapy",

abstract = "Magnetic-guided drug delivery system for cancer treatment can be realized by elaborating drug and magnetic nanoparticles (MNP) on the liposomes through the assistance of magnetic field exposure. Here, we prepared PEGylated liposomes (liposomes with poly-(ethylene glycol) (PEG) modification) to encapsulate doxorubicin (DOX) and MNP, termed as DOX-loaded PEGylated magnetic liposomes. We show that the DOX-loaded PEGylated magnetic liposomes exhibits spherical morphology with diameter about 100 nm, dispersed homogeneously in aqueous system and generate inductive heating from 37o to 56 °C by means of high-frequency magnetic field (HFMF) exposure. Moreover, DOX could kill HeLa cells due to DOX releasing indicating the DOX cytotoxicity to the HeLa cells as a function of DOX concentration. In conclusion, these liposomes could combine the function of DOX and MNP, opening a route as a drug carrier platform to enhance the therapeutic efficacy of chemotherapeutic drug and it could be integrated with the development of magnetic-guided drug delivery.",

keywords = "Cytocompatibility, Doxorubicin, Liposomes, Magnetic nanoparticles, Poly-(ethylene glycol)",

author = "Andri Hardiansyah and Fredina Destyorini and Yuyun Irmawati and Yang, {Ming Chien} and Liu, {Chi Ming} and Chaldun, {Elsy Rahimi} and Yung, {Ming Chi} and Liu, {Ting Yu}",

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doi = "10.1007/s10965-019-1964-5",

language = "English",

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AU - Hardiansyah, Andri

AU - Destyorini, Fredina

AU - Irmawati, Yuyun

AU - Yang, Ming Chien

AU - Liu, Chi Ming

AU - Chaldun, Elsy Rahimi

AU - Yung, Ming Chi

AU - Liu, Ting Yu

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Magnetic-guided drug delivery system for cancer treatment can be realized by elaborating drug and magnetic nanoparticles (MNP) on the liposomes through the assistance of magnetic field exposure. Here, we prepared PEGylated liposomes (liposomes with poly-(ethylene glycol) (PEG) modification) to encapsulate doxorubicin (DOX) and MNP, termed as DOX-loaded PEGylated magnetic liposomes. We show that the DOX-loaded PEGylated magnetic liposomes exhibits spherical morphology with diameter about 100 nm, dispersed homogeneously in aqueous system and generate inductive heating from 37o to 56 °C by means of high-frequency magnetic field (HFMF) exposure. Moreover, DOX could kill HeLa cells due to DOX releasing indicating the DOX cytotoxicity to the HeLa cells as a function of DOX concentration. In conclusion, these liposomes could combine the function of DOX and MNP, opening a route as a drug carrier platform to enhance the therapeutic efficacy of chemotherapeutic drug and it could be integrated with the development of magnetic-guided drug delivery.

AB - Magnetic-guided drug delivery system for cancer treatment can be realized by elaborating drug and magnetic nanoparticles (MNP) on the liposomes through the assistance of magnetic field exposure. Here, we prepared PEGylated liposomes (liposomes with poly-(ethylene glycol) (PEG) modification) to encapsulate doxorubicin (DOX) and MNP, termed as DOX-loaded PEGylated magnetic liposomes. We show that the DOX-loaded PEGylated magnetic liposomes exhibits spherical morphology with diameter about 100 nm, dispersed homogeneously in aqueous system and generate inductive heating from 37o to 56 °C by means of high-frequency magnetic field (HFMF) exposure. Moreover, DOX could kill HeLa cells due to DOX releasing indicating the DOX cytotoxicity to the HeLa cells as a function of DOX concentration. In conclusion, these liposomes could combine the function of DOX and MNP, opening a route as a drug carrier platform to enhance the therapeutic efficacy of chemotherapeutic drug and it could be integrated with the development of magnetic-guided drug delivery.

KW - Cytocompatibility

KW - Doxorubicin

KW - Liposomes

KW - Magnetic nanoparticles

KW - Poly-(ethylene glycol)

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Characterizations of doxorubicin-loaded PEGylated magnetic liposomes for cancer cells therapy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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