Characterization of the thrombogenic potential of surface oxides on stainless steel for implant purposes

Chun Che Shih, Chun Ming Shih, Yea Yang Su, Mau Song Chang, Shing Jong Lin

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)


Marketed stents are manufactured from various metals and passivated with different degrees of surface oxidation. The functional surface oxides on the degree of antithrombotic potential were explored through a canine femoral extracorporeal circuit model. Related properties of these oxide films were studied by open-circuit potential, current density detected at open-circuit potential, the electrochemical impedance spectroscopy, transmission electron microscopy, Auger spectroscopy (AES), X-ray photoelectron spectroscopy (XPS), and scanning electron microscopy. Experimental evidences showed that blood clot weight after a 30-min follow-up was significantly lower for the stainless steel wire passivated with amorphous oxide (AO) compared to the wire passivated with polycrystalline oxide (PO) or commercial as-received wire coils (AS). Surface characterizations showed that a stable negative current density at open-circuit potential and a significant lower potential were found for the wire surface passivated with AO than for the surface passivated with PO. Time constant of AO is about 25 times larger than that of polycrystalline oxide. Significant difference in oxide grain sizes was found between PO and AO. Surface chemistries revealed by the AES and XPS spectra indicated the presence of a Cr- and oxygen-rich surface oxide for AO, and a Fe-rich and oxygen-lean surface oxide for PO. These remarkable characteristics of AO surface film might have a potential to provide for excellent antithrombotic characteristics for the 316L stainless steel stents.

Original languageEnglish
Pages (from-to)347-362
Number of pages16
JournalApplied Surface Science
Issue number3-4
Publication statusPublished - Dec 15 2003


  • Amorphous oxide
  • Polycrystalline oxide
  • Stainless steel
  • Thrombosis
  • Time constant

ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics
  • Physics and Astronomy(all)
  • Surfaces and Interfaces
  • Surfaces, Coatings and Films


Dive into the research topics of 'Characterization of the thrombogenic potential of surface oxides on stainless steel for implant purposes'. Together they form a unique fingerprint.

Cite this