Characterization of class 1 integrons and gene cassettes in clinical isolates of Klebsiella pneumoniae from Taiwan

Chung Yu Chang; Yu Ti Fang; Shih Meng Tsai; Lin Li Chang; Wen Liang Yu

doi:10.1016/j.diagmicrobio.2009.06.005

Characterization of class 1 integrons and gene cassettes in clinical isolates of Klebsiella pneumoniae from Taiwan

Chung Yu Chang
, Yu Ti Fang
, Shih Meng Tsai
, Lin Li Chang
, Wen Liang Yu

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

We surveyed the prevalence and contents of class 1 integrons in clinical Klebsiella pneumoniae isolates collected from Kaohsiung, Taiwan, during 2 periods (1993 and 2004). Class 1 integrons were present in 78 isolates (34.2%) from 1993 (n = 228) and 129 (32.9%) from 2004 (n = 392) and contained varied gene cassette number, type, and array. We found 2 atypical sul3-associated class 1 integrons and identified 26 different gene cassettes, including an aac(6′)-Ib-cr cassette here firstly described in K. pneumoniae from Taiwan. The continuing evolution of class 1 integrons is threatening to undermine the effectiveness of antimicrobial therapy for K. pneumoniae.

Original language	English
Pages (from-to)	214-216
Number of pages	3
Journal	Diagnostic Microbiology and Infectious Disease
Volume	65
Issue number	2
DOIs	https://doi.org/10.1016/j.diagmicrobio.2009.06.005
Publication status	Published - Oct 2009

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Class 1 integrons
Gene cassettes
Klebsiella pneumoniae

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

Access to Document

10.1016/j.diagmicrobio.2009.06.005

Cite this

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title = "Characterization of class 1 integrons and gene cassettes in clinical isolates of Klebsiella pneumoniae from Taiwan",

abstract = "We surveyed the prevalence and contents of class 1 integrons in clinical Klebsiella pneumoniae isolates collected from Kaohsiung, Taiwan, during 2 periods (1993 and 2004). Class 1 integrons were present in 78 isolates (34.2\%) from 1993 (n = 228) and 129 (32.9\%) from 2004 (n = 392) and contained varied gene cassette number, type, and array. We found 2 atypical sul3-associated class 1 integrons and identified 26 different gene cassettes, including an aac(6′)-Ib-cr cassette here firstly described in K. pneumoniae from Taiwan. The continuing evolution of class 1 integrons is threatening to undermine the effectiveness of antimicrobial therapy for K. pneumoniae.",

keywords = "Class 1 integrons, Gene cassettes, Klebsiella pneumoniae",

author = "Chang, \{Chung Yu\} and Fang, \{Yu Ti\} and Tsai, \{Shih Meng\} and Chang, \{Lin Li\} and Yu, \{Wen Liang\}",

note = "Funding Information: This study was supported by a grant from the Chi Mei Medical Center and Kaohsiung Medical University Research Foundation (94CM-KMU-06).",

year = "2009",

month = oct,

doi = "10.1016/j.diagmicrobio.2009.06.005",

language = "English",

volume = "65",

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journal = "Diagnostic Microbiology and Infectious Disease",

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AU - Chang, Chung Yu

AU - Fang, Yu Ti

AU - Tsai, Shih Meng

AU - Chang, Lin Li

AU - Yu, Wen Liang

N1 - Funding Information: This study was supported by a grant from the Chi Mei Medical Center and Kaohsiung Medical University Research Foundation (94CM-KMU-06).

PY - 2009/10

Y1 - 2009/10

N2 - We surveyed the prevalence and contents of class 1 integrons in clinical Klebsiella pneumoniae isolates collected from Kaohsiung, Taiwan, during 2 periods (1993 and 2004). Class 1 integrons were present in 78 isolates (34.2%) from 1993 (n = 228) and 129 (32.9%) from 2004 (n = 392) and contained varied gene cassette number, type, and array. We found 2 atypical sul3-associated class 1 integrons and identified 26 different gene cassettes, including an aac(6′)-Ib-cr cassette here firstly described in K. pneumoniae from Taiwan. The continuing evolution of class 1 integrons is threatening to undermine the effectiveness of antimicrobial therapy for K. pneumoniae.

AB - We surveyed the prevalence and contents of class 1 integrons in clinical Klebsiella pneumoniae isolates collected from Kaohsiung, Taiwan, during 2 periods (1993 and 2004). Class 1 integrons were present in 78 isolates (34.2%) from 1993 (n = 228) and 129 (32.9%) from 2004 (n = 392) and contained varied gene cassette number, type, and array. We found 2 atypical sul3-associated class 1 integrons and identified 26 different gene cassettes, including an aac(6′)-Ib-cr cassette here firstly described in K. pneumoniae from Taiwan. The continuing evolution of class 1 integrons is threatening to undermine the effectiveness of antimicrobial therapy for K. pneumoniae.

KW - Class 1 integrons

KW - Gene cassettes

KW - Klebsiella pneumoniae

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U2 - 10.1016/j.diagmicrobio.2009.06.005

DO - 10.1016/j.diagmicrobio.2009.06.005

M3 - Article

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SN - 0732-8893

VL - 65

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Characterization of class 1 integrons and gene cassettes in clinical isolates of Klebsiella pneumoniae from Taiwan

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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