Characteristics of Chinese herbal medicine usage in ischemic heart disease patients among type 2 diabetes and their protection against hydrogen peroxide-mediated apoptosis in H9C2 cardiomyoblasts

Fuu Jen Tsai; Tsung Jung Ho; Chi Fung Cheng; Yi Tzone Shiao; Wen Kuei Chien; Jin Hua Chen; Xiang Liu; Hsinyi Tsang; Ting Hsu Lin; Chiu Chu Liao; Shao Mei Huang; Ju Pi Li; Cheng Wen Lin; Jaung Geng Lin; Yu Ching Lan; Yu Huei Liu; Chien Hui Hung; Jung Chun Lin; Chih Chien Lin; Chih Ho Lai; Wen Miin Liang; Ying Ju Lin

doi:10.18632/oncotarget.14657

Characteristics of Chinese herbal medicine usage in ischemic heart disease patients among type 2 diabetes and their protection against hydrogen peroxide-mediated apoptosis in H9C2 cardiomyoblasts

Fuu Jen Tsai, Tsung Jung Ho, Chi Fung Cheng, Yi Tzone Shiao, Wen Kuei Chien, Jin Hua Chen, Xiang Liu, Hsinyi Tsang, Ting Hsu Lin, Chiu Chu Liao, Shao Mei Huang, Ju Pi Li, Cheng Wen Lin, Jaung Geng Lin, Yu Ching Lan, Yu Huei Liu, Chien Hui Hung, Jung Chun Lin, Chih Chien Lin, Chih Ho LaiWen Miin Liang, Ying Ju Lin

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Evidence for long-term use of Chinese herbal medicine (CHM) as an adjuvant treatment in patients with type 2 diabetes (T2D) remains limited. This study aimed to assess the frequency of use, utilization patterns, and therapeutic effects of adjuvant CHM for ischemic heart disease (IHD) in patients with T2D in Taiwan. We identified 4620 IHD patients with T2D. After matching for age, gender, and insulin use, 988 subjects each were allocated to a CHM group and a non-CHM group. There were no differences in baseline characteristics except for comorbidities. The CHM group contained more cases with chronic obstructive pulmonary disease, hepatitis, ulcer disease, and hyperlipidemia. The cumulative survival probability was higher in CHM users than in matched non-CHM users aged 60 years or older (P < .0001, log rank test) regardless of gender (P = .0046 for men, P = .0010 for women, log rank test). Among the top 12 CHM combinations, Shu-Jing-Huo-Xue-Tang and Shao-Yao- Gan-Cao-Tang (13.6%) were the most common. This dual combination improved antiapoptotic activity in H2O2-exposed H9C2 cells by enhancing phosphorylation of glycogen synthase kinase-3ß and p38 mitogen-activated protein kinase and could increase the survival of myocardial cells. Our study suggests that adjuvant CHM therapy may increase the survival probability and provides a comprehensive list for future investigations of the safety and efficacy of CHM for IHD patients with T2D.

Original language	English
Pages (from-to)	15470-15489
Number of pages	20
Journal	Oncotarget
Volume	8
Issue number	9
DOIs	https://doi.org/10.18632/oncotarget.14657
Publication status	Published - 2017

Keywords

Cardiomyoblasts
Chinese herbal medicine
Ischemic heart disease
Oxidative stress
Type 2 diabetes

ASJC Scopus subject areas

Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.18632/oncotarget.14657

Cite this

Tsai, F. J., Ho, T. J., Cheng, C. F., Shiao, Y. T., Chien, W. K., Chen, J. H., Liu, X., Tsang, H., Lin, T. H., Liao, C. C., Huang, S. M., Li, J. P., Lin, C. W., Lin, J. G., Lan, Y. C., Liu, Y. H., Hung, C. H., Lin, J. C., Lin, C. C., ... Lin, Y. J. (2017). Characteristics of Chinese herbal medicine usage in ischemic heart disease patients among type 2 diabetes and their protection against hydrogen peroxide-mediated apoptosis in H9C2 cardiomyoblasts. Oncotarget, 8(9), 15470-15489. https://doi.org/10.18632/oncotarget.14657

Characteristics of Chinese herbal medicine usage in ischemic heart disease patients among type 2 diabetes and their protection against hydrogen peroxide-mediated apoptosis in H9C2 cardiomyoblasts. / Tsai, Fuu Jen; Ho, Tsung Jung; Cheng, Chi Fung et al.
In: Oncotarget, Vol. 8, No. 9, 2017, p. 15470-15489.

Research output: Contribution to journal › Article › peer-review

Tsai, FJ, Ho, TJ, Cheng, CF, Shiao, YT, Chien, WK, Chen, JH, Liu, X, Tsang, H, Lin, TH, Liao, CC, Huang, SM, Li, JP, Lin, CW, Lin, JG, Lan, YC, Liu, YH, Hung, CH, Lin, JC, Lin, CC, Lai, CH, Liang, WM & Lin, YJ 2017, 'Characteristics of Chinese herbal medicine usage in ischemic heart disease patients among type 2 diabetes and their protection against hydrogen peroxide-mediated apoptosis in H9C2 cardiomyoblasts', Oncotarget, vol. 8, no. 9, pp. 15470-15489. https://doi.org/10.18632/oncotarget.14657

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title = "Characteristics of Chinese herbal medicine usage in ischemic heart disease patients among type 2 diabetes and their protection against hydrogen peroxide-mediated apoptosis in H9C2 cardiomyoblasts",

abstract = "Evidence for long-term use of Chinese herbal medicine (CHM) as an adjuvant treatment in patients with type 2 diabetes (T2D) remains limited. This study aimed to assess the frequency of use, utilization patterns, and therapeutic effects of adjuvant CHM for ischemic heart disease (IHD) in patients with T2D in Taiwan. We identified 4620 IHD patients with T2D. After matching for age, gender, and insulin use, 988 subjects each were allocated to a CHM group and a non-CHM group. There were no differences in baseline characteristics except for comorbidities. The CHM group contained more cases with chronic obstructive pulmonary disease, hepatitis, ulcer disease, and hyperlipidemia. The cumulative survival probability was higher in CHM users than in matched non-CHM users aged 60 years or older (P < .0001, log rank test) regardless of gender (P = .0046 for men, P = .0010 for women, log rank test). Among the top 12 CHM combinations, Shu-Jing-Huo-Xue-Tang and Shao-Yao- Gan-Cao-Tang (13.6%) were the most common. This dual combination improved antiapoptotic activity in H2O2-exposed H9C2 cells by enhancing phosphorylation of glycogen synthase kinase-3{\ss} and p38 mitogen-activated protein kinase and could increase the survival of myocardial cells. Our study suggests that adjuvant CHM therapy may increase the survival probability and provides a comprehensive list for future investigations of the safety and efficacy of CHM for IHD patients with T2D.",

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author = "Tsai, {Fuu Jen} and Ho, {Tsung Jung} and Cheng, {Chi Fung} and Shiao, {Yi Tzone} and Chien, {Wen Kuei} and Chen, {Jin Hua} and Xiang Liu and Hsinyi Tsang and Lin, {Ting Hsu} and Liao, {Chiu Chu} and Huang, {Shao Mei} and Li, {Ju Pi} and Lin, {Cheng Wen} and Lin, {Jaung Geng} and Lan, {Yu Ching} and Liu, {Yu Huei} and Hung, {Chien Hui} and Lin, {Jung Chun} and Lin, {Chih Chien} and Lai, {Chih Ho} and Liang, {Wen Miin} and Lin, {Ying Ju}",

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AU - Tsai, Fuu Jen

AU - Ho, Tsung Jung

AU - Cheng, Chi Fung

AU - Shiao, Yi Tzone

AU - Chien, Wen Kuei

AU - Chen, Jin Hua

AU - Liu, Xiang

AU - Tsang, Hsinyi

AU - Lin, Ting Hsu

AU - Liao, Chiu Chu

AU - Huang, Shao Mei

AU - Li, Ju Pi

AU - Lin, Cheng Wen

AU - Lin, Jaung Geng

AU - Lan, Yu Ching

AU - Liu, Yu Huei

AU - Hung, Chien Hui

AU - Lin, Jung Chun

AU - Lin, Chih Chien

AU - Lai, Chih Ho

AU - Liang, Wen Miin

AU - Lin, Ying Ju

PY - 2017

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N2 - Evidence for long-term use of Chinese herbal medicine (CHM) as an adjuvant treatment in patients with type 2 diabetes (T2D) remains limited. This study aimed to assess the frequency of use, utilization patterns, and therapeutic effects of adjuvant CHM for ischemic heart disease (IHD) in patients with T2D in Taiwan. We identified 4620 IHD patients with T2D. After matching for age, gender, and insulin use, 988 subjects each were allocated to a CHM group and a non-CHM group. There were no differences in baseline characteristics except for comorbidities. The CHM group contained more cases with chronic obstructive pulmonary disease, hepatitis, ulcer disease, and hyperlipidemia. The cumulative survival probability was higher in CHM users than in matched non-CHM users aged 60 years or older (P < .0001, log rank test) regardless of gender (P = .0046 for men, P = .0010 for women, log rank test). Among the top 12 CHM combinations, Shu-Jing-Huo-Xue-Tang and Shao-Yao- Gan-Cao-Tang (13.6%) were the most common. This dual combination improved antiapoptotic activity in H2O2-exposed H9C2 cells by enhancing phosphorylation of glycogen synthase kinase-3ß and p38 mitogen-activated protein kinase and could increase the survival of myocardial cells. Our study suggests that adjuvant CHM therapy may increase the survival probability and provides a comprehensive list for future investigations of the safety and efficacy of CHM for IHD patients with T2D.

AB - Evidence for long-term use of Chinese herbal medicine (CHM) as an adjuvant treatment in patients with type 2 diabetes (T2D) remains limited. This study aimed to assess the frequency of use, utilization patterns, and therapeutic effects of adjuvant CHM for ischemic heart disease (IHD) in patients with T2D in Taiwan. We identified 4620 IHD patients with T2D. After matching for age, gender, and insulin use, 988 subjects each were allocated to a CHM group and a non-CHM group. There were no differences in baseline characteristics except for comorbidities. The CHM group contained more cases with chronic obstructive pulmonary disease, hepatitis, ulcer disease, and hyperlipidemia. The cumulative survival probability was higher in CHM users than in matched non-CHM users aged 60 years or older (P < .0001, log rank test) regardless of gender (P = .0046 for men, P = .0010 for women, log rank test). Among the top 12 CHM combinations, Shu-Jing-Huo-Xue-Tang and Shao-Yao- Gan-Cao-Tang (13.6%) were the most common. This dual combination improved antiapoptotic activity in H2O2-exposed H9C2 cells by enhancing phosphorylation of glycogen synthase kinase-3ß and p38 mitogen-activated protein kinase and could increase the survival of myocardial cells. Our study suggests that adjuvant CHM therapy may increase the survival probability and provides a comprehensive list for future investigations of the safety and efficacy of CHM for IHD patients with T2D.

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Characteristics of Chinese herbal medicine usage in ischemic heart disease patients among type 2 diabetes and their protection against hydrogen peroxide-mediated apoptosis in H9C2 cardiomyoblasts

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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