Characteristics of an alternative antibacterial biomaterial for mouthwash in the absence of alcohol

Chen Ying Su; Chia Chun Chen; Hsuan Yu Chen; Chun Pin Lin; Feng Huei Lin; Hsu Wei Fang

doi:10.1016/j.jds.2019.01.002

Characteristics of an alternative antibacterial biomaterial for mouthwash in the absence of alcohol

Chen Ying Su, Chia Chun Chen, Hsuan Yu Chen, Chun Pin Lin, Feng Huei Lin, Hsu Wei Fang

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Background/purpose: The purpose of this study was to investigate whether poly-gamma-glutamic acid (γ-PGA), a naturally derived biomaterial, was suitable as an alternative antibacterial mouthwash in the absence of alcohol. Materials and methods: Three bacterial strains, Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, were used for testing the antibacterial activity of mouthwashes. In addition, cell viability, cytotoxicity, and genotoxicity experiments were conducted for testing the toxicity of mouthwashes. Results: We demonstrated that 10000 ppm of γ-PGA without alcohol could efficiently inhibit 99% of bacterial growth. In addition, γ-PGA did not cause any cytotoxicity or genotoxicity. Conclusion: 10000 ppm of γ-PGA in an alcohol-free mouthwash is an alternative biomaterial for mouthwashes.

Original language	English
Pages (from-to)	192-197
Number of pages	6
Journal	Journal of Dental Sciences
Volume	14
Issue number	2
DOIs	https://doi.org/10.1016/j.jds.2019.01.002
Publication status	Published - Jun 1 2019
Externally published	Yes

Keywords

Biomaterials
Mouthwash
Poly-gamma-glutamic acid (γ-PGA)

ASJC Scopus subject areas

General Dentistry

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10.1016/j.jds.2019.01.002

Cite this

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title = "Characteristics of an alternative antibacterial biomaterial for mouthwash in the absence of alcohol",

abstract = "Background/purpose: The purpose of this study was to investigate whether poly-gamma-glutamic acid (γ-PGA), a naturally derived biomaterial, was suitable as an alternative antibacterial mouthwash in the absence of alcohol. Materials and methods: Three bacterial strains, Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, were used for testing the antibacterial activity of mouthwashes. In addition, cell viability, cytotoxicity, and genotoxicity experiments were conducted for testing the toxicity of mouthwashes. Results: We demonstrated that 10000 ppm of γ-PGA without alcohol could efficiently inhibit 99% of bacterial growth. In addition, γ-PGA did not cause any cytotoxicity or genotoxicity. Conclusion: 10000 ppm of γ-PGA in an alcohol-free mouthwash is an alternative biomaterial for mouthwashes.",

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author = "Su, {Chen Ying} and Chen, {Chia Chun} and Chen, {Hsuan Yu} and Lin, {Chun Pin} and Lin, {Feng Huei} and Fang, {Hsu Wei}",

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T1 - Characteristics of an alternative antibacterial biomaterial for mouthwash in the absence of alcohol

AU - Su, Chen Ying

AU - Chen, Chia Chun

AU - Chen, Hsuan Yu

AU - Lin, Chun Pin

AU - Lin, Feng Huei

AU - Fang, Hsu Wei

PY - 2019/6/1

Y1 - 2019/6/1

N2 - Background/purpose: The purpose of this study was to investigate whether poly-gamma-glutamic acid (γ-PGA), a naturally derived biomaterial, was suitable as an alternative antibacterial mouthwash in the absence of alcohol. Materials and methods: Three bacterial strains, Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, were used for testing the antibacterial activity of mouthwashes. In addition, cell viability, cytotoxicity, and genotoxicity experiments were conducted for testing the toxicity of mouthwashes. Results: We demonstrated that 10000 ppm of γ-PGA without alcohol could efficiently inhibit 99% of bacterial growth. In addition, γ-PGA did not cause any cytotoxicity or genotoxicity. Conclusion: 10000 ppm of γ-PGA in an alcohol-free mouthwash is an alternative biomaterial for mouthwashes.

AB - Background/purpose: The purpose of this study was to investigate whether poly-gamma-glutamic acid (γ-PGA), a naturally derived biomaterial, was suitable as an alternative antibacterial mouthwash in the absence of alcohol. Materials and methods: Three bacterial strains, Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, were used for testing the antibacterial activity of mouthwashes. In addition, cell viability, cytotoxicity, and genotoxicity experiments were conducted for testing the toxicity of mouthwashes. Results: We demonstrated that 10000 ppm of γ-PGA without alcohol could efficiently inhibit 99% of bacterial growth. In addition, γ-PGA did not cause any cytotoxicity or genotoxicity. Conclusion: 10000 ppm of γ-PGA in an alcohol-free mouthwash is an alternative biomaterial for mouthwashes.

KW - Biomaterials

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KW - Poly-gamma-glutamic acid (γ-PGA)

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Characteristics of an alternative antibacterial biomaterial for mouthwash in the absence of alcohol

Abstract

Keywords

ASJC Scopus subject areas

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