TY - JOUR
T1 - Characteristics of an alternative antibacterial biomaterial for mouthwash in the absence of alcohol
AU - Su, Chen Ying
AU - Chen, Chia Chun
AU - Chen, Hsuan Yu
AU - Lin, Chun Pin
AU - Lin, Feng Huei
AU - Fang, Hsu Wei
N1 - Funding Information:
This work and all the commercial products were supported by Purzer Pharmaceutical Co. Ltd (Taipei, Taiwan).
Funding Information:
This work and all the commercial products were supported by Purzer Pharmaceutical Co., Ltd (Taipei, Taiwan).
Publisher Copyright:
© 2019 Association for Dental Sciences of the Republic of China
PY - 2019/6/1
Y1 - 2019/6/1
N2 - Background/purpose: The purpose of this study was to investigate whether poly-gamma-glutamic acid (γ-PGA), a naturally derived biomaterial, was suitable as an alternative antibacterial mouthwash in the absence of alcohol. Materials and methods: Three bacterial strains, Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, were used for testing the antibacterial activity of mouthwashes. In addition, cell viability, cytotoxicity, and genotoxicity experiments were conducted for testing the toxicity of mouthwashes. Results: We demonstrated that 10000 ppm of γ-PGA without alcohol could efficiently inhibit 99% of bacterial growth. In addition, γ-PGA did not cause any cytotoxicity or genotoxicity. Conclusion: 10000 ppm of γ-PGA in an alcohol-free mouthwash is an alternative biomaterial for mouthwashes.
AB - Background/purpose: The purpose of this study was to investigate whether poly-gamma-glutamic acid (γ-PGA), a naturally derived biomaterial, was suitable as an alternative antibacterial mouthwash in the absence of alcohol. Materials and methods: Three bacterial strains, Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, were used for testing the antibacterial activity of mouthwashes. In addition, cell viability, cytotoxicity, and genotoxicity experiments were conducted for testing the toxicity of mouthwashes. Results: We demonstrated that 10000 ppm of γ-PGA without alcohol could efficiently inhibit 99% of bacterial growth. In addition, γ-PGA did not cause any cytotoxicity or genotoxicity. Conclusion: 10000 ppm of γ-PGA in an alcohol-free mouthwash is an alternative biomaterial for mouthwashes.
KW - Biomaterials
KW - Mouthwash
KW - Poly-gamma-glutamic acid (γ-PGA)
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U2 - 10.1016/j.jds.2019.01.002
DO - 10.1016/j.jds.2019.01.002
M3 - Article
AN - SCOPUS:85063114556
SN - 1991-7902
VL - 14
SP - 192
EP - 197
JO - Journal of Dental Sciences
JF - Journal of Dental Sciences
IS - 2
ER -