TY - JOUR
T1 - Characteristics and cytotoxicity of indoor fine particulate matter (PM2.5) and PM2.5-bound polycyclic aromatic hydrocarbons (PAHs) in Hong Kong
AU - Tong, Xinning
AU - Chen, Xiao Cui
AU - Chuang, Hsiao Chi
AU - Cao, Jun Ji
AU - Ho, Steven Sai Hang
AU - Lui, Ka Hei
AU - Ho, K. F.
N1 - Funding Information:
This study was funded by the Research Grants Council of the Hong Kong Special Administrative Region of China (grant no. 14212116) and supported by the Ministry of Science and Technology of China (2013FY112700).
Funding Information:
Xiao-Cui Chen acknowledges the Vice-Chancellor’s Discretionary Fund of The Chinese University of Hong Kong (project no. 4930744). The English language of the manuscript was edited by Wallace Academic Editing. The authors would like to thank all study subjects and field/laboratory technicians who participated in this campaign.
Funding Information:
Xiao-Cui Chen acknowledges the Vice-Chancellor?s Discretionary Fund of The Chinese University of Hong Kong (project no. 4930744). The English language of the manuscript was edited by Wallace Academic Editing. The authors would like to thank all study subjects and field/laboratory technicians who participated in this campaign.
Publisher Copyright:
© 2019, Springer Nature B.V.
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Organic components of fine particles, especially polycyclic aromatic hydrocarbons (PAHs), play an essential role in the toxicity of fine particulate matter (PM2.5). The chemical and bioreactive properties of PM2.5 in indoor environments were investigated from 2014 to 2016 in Hong Kong among 33 residential indoor environments. All analyzed components revealed higher concentrations in winter than in summer, except for organic carbon (OC). High molecular weight PAHs (4–6 rings) contributed higher total PAH compositions than low molecular weight PAHs (2–3 rings). The study results suggested that the major sources of indoor PM2.5 originated from outdoor vehicle emissions, indoor cooking activities, and incense burning. Cytotoxicity tests only revealed significant associations in winter. The cell viability demonstrated strong negative correlations between OC (r = − 0.8, p < 0.05), total PM2.5-bound PAHs (r = − 0.6, p < 0.05), and United States Environmental Protection Agency (US EPA) priority PAHs (r = − 0.7, p < 0.05). Cell lactate dehydrogenase (LDH) and 8-isoprostane were positively associated with OC (r = 0.8, p < 0.05; r = 0.7, p < 0.05), total PM2.5-bound PAH (r = 0.7, p < 0.05; r = 0.7, p < 0.05), and US EPA priority PAH (r = 0.6, p < 0.05; r = 0.5, p = 0.07) concentrations. IL-6 had the only positive association with OC (r = 0.5, p < 0.05). This study focused on indoor PM2.5 levels and the associated cytotoxicity in the absence of environmental tobacco smoke.
AB - Organic components of fine particles, especially polycyclic aromatic hydrocarbons (PAHs), play an essential role in the toxicity of fine particulate matter (PM2.5). The chemical and bioreactive properties of PM2.5 in indoor environments were investigated from 2014 to 2016 in Hong Kong among 33 residential indoor environments. All analyzed components revealed higher concentrations in winter than in summer, except for organic carbon (OC). High molecular weight PAHs (4–6 rings) contributed higher total PAH compositions than low molecular weight PAHs (2–3 rings). The study results suggested that the major sources of indoor PM2.5 originated from outdoor vehicle emissions, indoor cooking activities, and incense burning. Cytotoxicity tests only revealed significant associations in winter. The cell viability demonstrated strong negative correlations between OC (r = − 0.8, p < 0.05), total PM2.5-bound PAHs (r = − 0.6, p < 0.05), and United States Environmental Protection Agency (US EPA) priority PAHs (r = − 0.7, p < 0.05). Cell lactate dehydrogenase (LDH) and 8-isoprostane were positively associated with OC (r = 0.8, p < 0.05; r = 0.7, p < 0.05), total PM2.5-bound PAH (r = 0.7, p < 0.05; r = 0.7, p < 0.05), and US EPA priority PAH (r = 0.6, p < 0.05; r = 0.5, p = 0.07) concentrations. IL-6 had the only positive association with OC (r = 0.5, p < 0.05). This study focused on indoor PM2.5 levels and the associated cytotoxicity in the absence of environmental tobacco smoke.
KW - Cytotoxicity
KW - Indoor air
KW - Organic carbon, PAHs
KW - PM
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U2 - 10.1007/s11869-019-00762-0
DO - 10.1007/s11869-019-00762-0
M3 - Article
AN - SCOPUS:85074685567
SN - 1873-9318
VL - 12
SP - 1459
EP - 1468
JO - Air Quality, Atmosphere and Health
JF - Air Quality, Atmosphere and Health
IS - 12
ER -