Characterisation and molecular epidemiology of extended-spectrum β-lactamase-producing Enterobacter cloacae isolated from a district teaching hospital in Taiwan

Wen-Liang Yu; Kuo-Chen Cheng; Chizh Ju Chi; Hui E. Chen; Yin Ching Chuang; Lii Tzu Wu

doi:10.1111/j.1469-0691.2006.01384.x

Characterisation and molecular epidemiology of extended-spectrum β-lactamase-producing Enterobacter cloacae isolated from a district teaching hospital in Taiwan

Wen-Liang Yu, Kuo-Chen Cheng, Chizh Ju Chi, Hui E. Chen, Yin Ching Chuang, Lii Tzu Wu

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Enterobacter cloacae (n = 110) isolates from a district hospital in Taiwan were screened for extended-spectrum β-lactamases (ESBLs). In total, 17 ESBL-producers were identified, based on the combination-disk synergy test using cefotaxime and ceftazidime ± clavulanic acid. Investigation of ESBL genes in 33 ceftazidime-resistant isolates revealed the SHV-12 gene in the same 17 ESBL-producers. In addition, one isolate also carried the CTX-M-3 gene, and two isolates also carried the CTX-M-9 gene. No major epidemic clone of ESBL-producers was identified by pulsed-field gel electrophoresis. Routine screening for the ESBL phenotype, focusing on ceftazidime-resistant E. cloacae, should be undertaken in this area.

Original language	English
Pages (from-to)	579-582
Number of pages	4
Journal	Clinical Microbiology and Infection
Volume	12
Issue number	6
DOIs	https://doi.org/10.1111/j.1469-0691.2006.01384.x
Publication status	Published - Jun 2006

Keywords

CTX-M-3
CTX-M-9
Enterobacter cloacae
Extended-spectrum β-lactamases
SHV-12

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1469-0691.2006.01384.x

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title = "Characterisation and molecular epidemiology of extended-spectrum β-lactamase-producing Enterobacter cloacae isolated from a district teaching hospital in Taiwan",

abstract = "Enterobacter cloacae (n = 110) isolates from a district hospital in Taiwan were screened for extended-spectrum β-lactamases (ESBLs). In total, 17 ESBL-producers were identified, based on the combination-disk synergy test using cefotaxime and ceftazidime ± clavulanic acid. Investigation of ESBL genes in 33 ceftazidime-resistant isolates revealed the SHV-12 gene in the same 17 ESBL-producers. In addition, one isolate also carried the CTX-M-3 gene, and two isolates also carried the CTX-M-9 gene. No major epidemic clone of ESBL-producers was identified by pulsed-field gel electrophoresis. Routine screening for the ESBL phenotype, focusing on ceftazidime-resistant E. cloacae, should be undertaken in this area.",

keywords = "CTX-M-3, CTX-M-9, Enterobacter cloacae, Extended-spectrum β-lactamases, SHV-12",

author = "Wen-Liang Yu and Kuo-Chen Cheng and Chi, {Chizh Ju} and Chen, {Hui E.} and Chuang, {Yin Ching} and Wu, {Lii Tzu}",

year = "2006",

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doi = "10.1111/j.1469-0691.2006.01384.x",

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AU - Yu, Wen-Liang

AU - Cheng, Kuo-Chen

AU - Chi, Chizh Ju

AU - Chen, Hui E.

AU - Chuang, Yin Ching

AU - Wu, Lii Tzu

PY - 2006/6

Y1 - 2006/6

N2 - Enterobacter cloacae (n = 110) isolates from a district hospital in Taiwan were screened for extended-spectrum β-lactamases (ESBLs). In total, 17 ESBL-producers were identified, based on the combination-disk synergy test using cefotaxime and ceftazidime ± clavulanic acid. Investigation of ESBL genes in 33 ceftazidime-resistant isolates revealed the SHV-12 gene in the same 17 ESBL-producers. In addition, one isolate also carried the CTX-M-3 gene, and two isolates also carried the CTX-M-9 gene. No major epidemic clone of ESBL-producers was identified by pulsed-field gel electrophoresis. Routine screening for the ESBL phenotype, focusing on ceftazidime-resistant E. cloacae, should be undertaken in this area.

AB - Enterobacter cloacae (n = 110) isolates from a district hospital in Taiwan were screened for extended-spectrum β-lactamases (ESBLs). In total, 17 ESBL-producers were identified, based on the combination-disk synergy test using cefotaxime and ceftazidime ± clavulanic acid. Investigation of ESBL genes in 33 ceftazidime-resistant isolates revealed the SHV-12 gene in the same 17 ESBL-producers. In addition, one isolate also carried the CTX-M-3 gene, and two isolates also carried the CTX-M-9 gene. No major epidemic clone of ESBL-producers was identified by pulsed-field gel electrophoresis. Routine screening for the ESBL phenotype, focusing on ceftazidime-resistant E. cloacae, should be undertaken in this area.

KW - CTX-M-3

KW - CTX-M-9

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KW - Extended-spectrum β-lactamases

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Characterisation and molecular epidemiology of extended-spectrum β-lactamase-producing Enterobacter cloacae isolated from a district teaching hospital in Taiwan

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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