TY - JOUR
T1 - Changes in cerebral autoregulation and blood biomarkers after remote ischemic preconditioning
AU - Guo, Zhen Ni
AU - Guo, Wei Tong
AU - Liu, Jia
AU - Chang, Junlei
AU - Ma, Hongyin
AU - Zhang, Peng
AU - Zhang, Fu Liang
AU - Han, Ke
AU - Hu, Han Hwa
AU - Jin, Hang
AU - Sun, Xin
AU - Simpson, David Martin
AU - Yang, Yi
N1 - Funding Information:
From the Stroke Center (Z.-N.G., W.-T.G., H.M., F.-L.Z., H.J., X.S., Y.Y.) and Clinical Trial and Research Center for Stroke (Z.-N.G., P.Z., Y.Y.), Department of Neurology, First Hospital of Jilin University, Changchun; Laboratory for Engineering and Scientific Computing, Institute of Advanced Computing and Digital Engineering (J.L.) and Center for Antibody Drug, Institute of Biomedicine and Biotechnology (J.C.), Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen University Town; Department of Neurology (K.H.), Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China; Department of Neurology, Taipei Medical University-Shaung Ho Hospital (H.-H.H.), and Cerebrovascular Treatment and Research Center (H.-H.H.), College of Medicine, Taipei Medical University, Taiwan; and Institute of Sound and Vibration Research (D.M.S.), University of Southampton, UK.
Funding Information:
The Article Processing Charge was funded by the National Key R&D Program of China (2016YFC1301600).
Funding Information:
This article was supported by the National Key R&D Program of China (2016YFC1301600) and Program for JLU Science and Technology Innovative Research Team (2017TD-12) to Yi Yang.
Publisher Copyright:
© American Academy of Neurology.
PY - 2019/7
Y1 - 2019/7
N2 - ObjectiveTo determine the effect of remote ischemic preconditioning (RIPC) on dynamic cerebral autoregulation (dCA) and various blood biomarkers in healthy adults.MethodsA self-controlled interventional study was conducted. Serial measurements of dCA were performed at 7 time points (7, 9, and 11 am; 2, 5, and 8 pm, and 8 am on the next day) without or with RIPC, carried out at 7:20 to 8 am. Venous blood samples were collected at baseline (7 am) and 1 hour after RIPC, and blood biomarkers, including 5 neuroprotective factors and 25 inflammation-related biomarkers, were measured with a quantitative protein chip.ResultsFifty participants were enrolled (age 34.54 ± 12.01 years, 22 men). Compared with the results on the day without RIPC, dCA was significantly increased at 6 hours after RIPC, and the increase was sustained for at least 24 hours. After RIPC, 2 neuroprotective factors (glial cell-derived neurotrophic factor and vascular endothelial growth factor-A) and 4 inflammation-related biomarkers (transforming growth factor-β1, leukemia inhibitory factor, matrix metallopeptidase-9, and tissue inhibitor of metalloproteinase-1) were significantly elevated compared with their baseline levels. Conversely, monocyte chemoattractant protein-1 was significantly lower compared with its baseline level.ConclusionsRIPC induces a sustained increase of dCA from 6 to at least 24 hours after treatment in healthy adults. In addition, several neuroprotective and inflammation-related blood biomarkers were differentially regulated shortly after RIPC. The increased dCA and altered blood biomarkers may collectively contribute to the beneficial effects of RIPC on cerebrovascular function.ClinicalTrials.gov identifier:NCT02965547.
AB - ObjectiveTo determine the effect of remote ischemic preconditioning (RIPC) on dynamic cerebral autoregulation (dCA) and various blood biomarkers in healthy adults.MethodsA self-controlled interventional study was conducted. Serial measurements of dCA were performed at 7 time points (7, 9, and 11 am; 2, 5, and 8 pm, and 8 am on the next day) without or with RIPC, carried out at 7:20 to 8 am. Venous blood samples were collected at baseline (7 am) and 1 hour after RIPC, and blood biomarkers, including 5 neuroprotective factors and 25 inflammation-related biomarkers, were measured with a quantitative protein chip.ResultsFifty participants were enrolled (age 34.54 ± 12.01 years, 22 men). Compared with the results on the day without RIPC, dCA was significantly increased at 6 hours after RIPC, and the increase was sustained for at least 24 hours. After RIPC, 2 neuroprotective factors (glial cell-derived neurotrophic factor and vascular endothelial growth factor-A) and 4 inflammation-related biomarkers (transforming growth factor-β1, leukemia inhibitory factor, matrix metallopeptidase-9, and tissue inhibitor of metalloproteinase-1) were significantly elevated compared with their baseline levels. Conversely, monocyte chemoattractant protein-1 was significantly lower compared with its baseline level.ConclusionsRIPC induces a sustained increase of dCA from 6 to at least 24 hours after treatment in healthy adults. In addition, several neuroprotective and inflammation-related blood biomarkers were differentially regulated shortly after RIPC. The increased dCA and altered blood biomarkers may collectively contribute to the beneficial effects of RIPC on cerebrovascular function.ClinicalTrials.gov identifier:NCT02965547.
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U2 - 10.1212/WNL.0000000000007732
DO - 10.1212/WNL.0000000000007732
M3 - Article
C2 - 31142636
AN - SCOPUS:85069264608
SN - 0028-3878
VL - 93
SP - E8-E19
JO - Neurology
JF - Neurology
IS - 1
ER -