TY - JOUR
T1 - Changes in arachidonate metabolism in aortas and platelets in aging rats
AU - Chang, Wen Chang
AU - Tai, Hsin Hsiung
N1 - Funding Information:
The authors wish to thank the National Institute on Aging, NIH for the supply of animals and to Mrs. Sharon Parker for her excellent technical assistance. This work was supported in part from the National Institutes of Health (GM-30380), the American Heart Association (81-1152), the American Heart Association Kentucky Affiliate, Inc. and the University of Kentucky Isabel1 L. Kircher Fund.
PY - 1983/10
Y1 - 1983/10
N2 - Prostacyclin formation by aortas, thromboxane biosynthesis and 12-lipoxygenase pathway in platelets as a function of age was investigated. Our results indicate an age-related decrease in prostacyclin production by aortas, while no significant change in thromboxane biosynthesis in platelets from mature (12 month old) to senescent (24 month old) rats was observed. Evidence is also presented indicating a decrease in 12-L-hydroperoxy-5,8,10,14-eicosatetraenoic acid (12-HPETE) peroxidase activity in platelets as a function of age.
AB - Prostacyclin formation by aortas, thromboxane biosynthesis and 12-lipoxygenase pathway in platelets as a function of age was investigated. Our results indicate an age-related decrease in prostacyclin production by aortas, while no significant change in thromboxane biosynthesis in platelets from mature (12 month old) to senescent (24 month old) rats was observed. Evidence is also presented indicating a decrease in 12-L-hydroperoxy-5,8,10,14-eicosatetraenoic acid (12-HPETE) peroxidase activity in platelets as a function of age.
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U2 - 10.1016/0262-1746(83)90078-1
DO - 10.1016/0262-1746(83)90078-1
M3 - Article
C2 - 6417674
AN - SCOPUS:0021046323
SN - 0262-1746
VL - 12
SP - 149
EP - 157
JO - Prostaglandins, Leukotrienes and Medicine
JF - Prostaglandins, Leukotrienes and Medicine
IS - 2
ER -