Change in symptom clusters in head and neck cancer patients undergoing postoperative radiotherapy: A longitudinal study

S. H. Chiang, K. Y. Ho, Shu-Yi Wang, C. C. Lin

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


Purpose: Research on symptom clusters is a newly emerging field in oncology; however, little evidence regarding symptom clusters in head and neck cancer (HNC) is currently available. To clarify this under-researched area, we investigated symptom clusters among patients with HNC treated with surgery and postoperative radiotherapy. We also examined the pattern of symptom clusters throughout the treatment course. Method: A convenience sample of 100 patients with HNC was recruited in the Ear, Nose, and Throat unit of a medical center in Taiwan. Before undergoing postoperative radiotherapy, patients were asked to complete the MD Anderson Symptom Inventory and a demographic sheet. Patients completed the same inventory questionnaire at week 1, 2, 3, 4, 5, and 6 of radiotherapy. Result: Two symptom clusters were observed, and they were stable throughout the course of radiotherapy. Cluster 1, the HNC-specific cluster, comprised the symptoms of pain, dry mouth, lack of appetite, sleep disturbance, fatigue, drowsiness, distress, and sadness. Cluster 2, the gastrointestinal cluster, included nausea, vomiting, numbness, shortness of breath, and difficulty remembering. Conclusion: This study advanced our knowledge of symptom clusters in patients with HNC. The results are expected to contribute to the development of appropriate assessment and nursing interventions targeting multiple symptoms that may coexist in postoperative radiotherapy.

Original languageEnglish
Pages (from-to)62-66
Number of pages5
JournalEuropean Journal of Oncology Nursing
Publication statusPublished - Aug 1 2018


  • Head and neck cancer
  • Longitudinal study
  • Radiotherapy
  • Symptom clusters
  • Humans
  • Middle Aged
  • Postoperative Period
  • Male
  • Head and Neck Neoplasms/radiotherapy
  • Syndrome
  • Radiotherapy/adverse effects
  • Taiwan
  • Adult
  • Female
  • Surveys and Questionnaires
  • Aged
  • Longitudinal Studies

ASJC Scopus subject areas

  • Oncology(nursing)


Dive into the research topics of 'Change in symptom clusters in head and neck cancer patients undergoing postoperative radiotherapy: A longitudinal study'. Together they form a unique fingerprint.

Cite this