Chalcone based azacarboline analogues as novel antitubulin agents: Design, synthesis, biological evaluation and molecular modelling studies

Chemistry

• % Inhibition 100%
• IC50 100%
• Molecular Modeling 100%
• Chalcone 100%
• Structure 50%
• Binding Site 50%
• Polymerization 50%
• Methoxy Group 50%
• Structure-Activity Relationship 50%
• Colchicine 50%
• Indole 50%
• Hydrogen Bonding 50%
• Acetyl 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Tubulin 100%
• Chalcone 100%
• Cytotoxicity 66%
• IC50 66%
• Malignant Neoplasm 33%
• Binding Site 33%
• Acetic Acid Derivative 33%
• Colchicine 33%
• Structure Activity Relationship 33%
• Indole Derivative 33%