TY - JOUR
T1 - Cerebral response to patient's own name in the vegetative and minimally conscious states
AU - Di, Haibo
AU - Yu, Senming
AU - Weng, Xuchu
AU - Laureys, Steven
AU - Yu, Dan
AU - Li, J.Q.
AU - Qin, Pengmin
AU - Zhu, Yihong
AU - Zhang, Suzhan
AU - Chen, Yu
N1 - 被引用次數：177
Export Date: 31 March 2016
CODEN: NEURA
通訊地址: Chen, Y.Z.; Zhejiang University School of Medicine, Hangzhou 310006, China; 電子郵件： [email protected]
參考文獻: Laureys, S., Owen, A.M., Schiff, N.D., Brain function in coma, vegetative state, and related disorders (2004) Lancet Neurol, 3, pp. 537-546; Schiff, N.D., Modeling the minimally conscious state: Measurements of brain function and therapeutic possibilities (2005) Prog Brain Res, 150, pp. 473-493; Laureys, S., Faymonville, M.E., Degueldre, C., Auditory processing in the vegetative state (2000) Brain, 123, pp. 1589-1601; Boly, M., Faymonville, M.E., Peigneux, P., Auditory processing in severely brain injured patients: Differences between the minimally conscious state and the persistent vegetative state (2004) Arch Neurol, 61, pp. 233-238; De Jong, B.M., Willemsen, A.T.M., Paas, A.M.J., (1997) Regional cerebral blood flow changes related to affective speech presentation in persistent vegetative state. Clin Neurol Neurosurg, 99, pp. 213-216; Owen, A.M., Coleman, M.R., Menon, D.K., Residual auditory function in persistent vegetative state: A combined PET and fMRI study (2005) Neuropsychol Rehabil, 15, pp. 290-306; Menon, D.K., Owen, A.M., Williams, E.J., Cortical processing in persistent vegetative state (1998) Lancet, 352, p. 200; Owen, A.M., Menon, D.K., Johnsrude, I.S., Detecting residual cognitive function in persistent vegetative state (2002) Neurocase, 8, pp. 394-403; Mack, A., Pappas, Z., Silverman, M., Gay, R., What we see: Inattention and the capture of attention by meaning (2002) Conscious Cogn, 11, pp. 488-506; Laureys, S., Perrin, F., Faymonville, M.E., Cerebral processing in the minimally conscious state (2004) Neurology, 63, pp. 916-918; Holeckova, I., Fischer, C., Giard, M.-H., Delpuech, C., Morlet, D., Brain response to a subject's own name uttered by a familiar voice (2006) Brain Res, 1082, pp. 142-152; Born, J.D., Hans, P., Dexters, G., Practical assessment of brain dysfunction in severe head trauma (author's transl)] (1982) Neurochirurgie, 28, pp. 1-7; Teasdale, G., Jennett, B., Assessment of coma and impaired consciousness. A practical scale (1974) Lancet, 2, pp. 81-84; Giacino, J.T., Kalmar, K., Whyte, J., The JFK Coma Recovery Scale-Revised: Measurement characteristics and diagnostic utility (2004) Arch Phys Med Rehabil, 85, pp. 2020-2029; Shiel, A., Horn, S., Wilson, B.A., The Wessex Head Injury Matrix main scale: A preliminary report on a scale to assess and monitor patients recovery after severe head injury (2000) Clin Rehabil, 14, pp. 408-416; Wade, D.T., Johnston, C., The permanent vegetative state: Practical guidance on diagnosis and management (1999) BMJ, 319, pp. 841-844; Meeting summary-expert forum for drawing Chinese diagnostic criterion for VS. Chin J Emerg Med 2002;11:241Xiang, H., Lin, C., Ma, X., Involvement of the cerebellum in semantic discrimination: An fMRI study (2003) Hum Brain Mapp, 18, pp. 208-214; Xiao, Z., Lee, T., Zhang, J.X., Thirsty heroin addicts show different fMRI activations when exposed to water-related and drug-related cues (2006) Drug Alcohol Depend, 83, pp. 157-162; Cox, R.W., AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages (1996) Comput Biomed Res, 29, pp. 162-173; Ward, B.D., (2006) Simultaneous inference for fMRI, , http://afni.nimh.nih.gov/pub/dist/doc/manual, data. Available at: Accessed December 25; Campain, R., Minckler, J., A note on the gross configurations of the human auditory cortex (1976) Brain Lang, 3, pp. 318-323; Jancke, L., Schlaug, G., Huang, Y., Steinmetz, H., Asymmetry of the planum parietale (1994) Neuroreport, 5, pp. 1161-1163; Emmorey, K., Allen, J.S., Bruss, J., Schenker, N., Damasio, H., A morphometric analysis of auditory brain regions in congenitally deaf adults (2003) Proc Natl Acad Sci USA, 100, pp. 10049-10054; Majerus, S., Gill-Thwaites, H., Andrews, K., Laureys, S., Behavioral evaluation of consciousness in severe brain damage (2005) Prog Brain Res, 150, pp. 397-413; Andrews, K., Murphy, L., Munday, R., Littlewood, C., Misdiagnosis of the vegetative state: Retrospective study in a rehabilitation unit (1996) BMJ, 313, pp. 13-16; Schiff, N.D., Rodriguez-Moreno, D., Kamal, A., fMRI reveals largescale network activation in minimally conscious patients (2005) Neurology, 64, pp. 514-523; Perrin, F., Maquet, P., Peigneux, P., Neural mechanisms involved in the detection of our first name: A combined ERPs and PET study (2005) Neuropsychologia, 43, pp. 12-19; Kjaer, T.W., Nowak, M., Lou, H.C., Reflective self-awareness and conscious states: PET evidence for a common midline parietofrontal core (2002) Neuroimage, 17, pp. 1080-1086; Vogeley, K., Bussfeld, P., Newen, A., Mind reading: Neural mechanisms of theory of mind and self-perspective (2001) Neuroimage, 14, pp. 170-181
PY - 2007
Y1 - 2007
N2 - BACKGROUND: A challenge in the management of severely brain-damaged patients with altered states of consciousness is the differential diagnosis between the vegetative state (VS) and the minimally conscious state (MCS), especially for the gray zone separating these clinical entities. OBJECTIVE: To evaluate the differences in brain activation in response to presentation of the patient's own name spoken by a familiar voice (SON-FV) in patients with VS and MCS. METHODS: By using fMRI, we prospectively studied residual cerebral activation to SON-FV in seven patients with VS and four with MCS. Behavioral evaluation was performed by means of standardized testing up to 3 months post-fMRI. RESULTS: Two patients with VS failed to show any significant cerebral activation. Three patients with VS showed SON-FV induced activation within the primary auditory cortex. Finally, two patients with VS and all four patients with MCS not only showed activation in primary auditory cortex but also in hierarchically higher order associative temporal areas. These two patients with VS showing the most widespread activation subsequently showed clinical improvement to MCS observed 3 months after their fMRI scan. CONCLUSION: The cerebral responses to patient's own name spoken by a familiar voice as measured by fMRI might be a useful tool to preclinically distinguish minimally conscious state-like cognitive processing in some patients behaviorally classified as vegetative. ©2007AAN Enterprises, Inc.
AB - BACKGROUND: A challenge in the management of severely brain-damaged patients with altered states of consciousness is the differential diagnosis between the vegetative state (VS) and the minimally conscious state (MCS), especially for the gray zone separating these clinical entities. OBJECTIVE: To evaluate the differences in brain activation in response to presentation of the patient's own name spoken by a familiar voice (SON-FV) in patients with VS and MCS. METHODS: By using fMRI, we prospectively studied residual cerebral activation to SON-FV in seven patients with VS and four with MCS. Behavioral evaluation was performed by means of standardized testing up to 3 months post-fMRI. RESULTS: Two patients with VS failed to show any significant cerebral activation. Three patients with VS showed SON-FV induced activation within the primary auditory cortex. Finally, two patients with VS and all four patients with MCS not only showed activation in primary auditory cortex but also in hierarchically higher order associative temporal areas. These two patients with VS showing the most widespread activation subsequently showed clinical improvement to MCS observed 3 months after their fMRI scan. CONCLUSION: The cerebral responses to patient's own name spoken by a familiar voice as measured by fMRI might be a useful tool to preclinically distinguish minimally conscious state-like cognitive processing in some patients behaviorally classified as vegetative. ©2007AAN Enterprises, Inc.
KW - adult
KW - article
KW - auditory cortex
KW - auditory stimulation
KW - behavior
KW - brain function
KW - clinical article
KW - cognition
KW - controlled study
KW - female
KW - functional magnetic resonance imaging
KW - human
KW - male
KW - minimally conscious state
KW - persistent vegetative state
KW - priority journal
KW - prospective study
KW - voice
KW - Acoustic Stimulation
KW - Adult
KW - Auditory Cortex
KW - Auditory Perception
KW - Awareness
KW - Brain Mapping
KW - Cerebral Cortex
KW - Consciousness
KW - Diagnosis, Differential
KW - Female
KW - Humans
KW - Magnetic Resonance Imaging
KW - Male
KW - Middle Aged
KW - Nerve Net
KW - Persistent Vegetative State
KW - Predictive Value of Tests
KW - Prospective Studies
U2 - 10.1212/01.wnl.0000258544.79024.d0
DO - 10.1212/01.wnl.0000258544.79024.d0
M3 - Article
SN - 0028-3878
VL - 68
SP - 895
EP - 899
JO - Neurology
JF - Neurology
IS - 12
ER -