@article{12c9ef256cea45a5a6045ae99d673521,
title = "Cerebral columnar organization of the first nociceptive component induced by CO2 laser on the tail of the rat",
abstract = "The somatotopic map of the first nociceptive component in the primary somatosensory cortex (S1) is still unclear. In this study, a CO2 laser was applied to the tail of the rat to induce nociception without the interference from large myelinated (Aβ) fibers. Thus, only noxious fibers could be activated. Two-dimensional current-source-density analysis was used to analyze the evoked field potentials. Using this method, the nociceptive responses of Aδ-fibers in S1 were verified, and the somatotopic map of the first nociceptive component in S1 was identified. We found that whether light touch or laser-induced nociception was applied to the tail of the rat, the responsive topography in S1 was consistent. Discrimination of these two modalities was achieved vertically in the same column; the deeper layer represented the nociceptive response while the superficial layer encoded the response to light touch. This is quite different from that of a primate brain. {\textcopyright} 2009 IBRO.",
keywords = "CO2 laser, cortex, current source density, evoked potentials, nociception, rat tail, carbon dioxide, afferent nerve group 1, animal experiment, article, brain mapping, controlled study, electric potential, evoked response, laser, male, nerve fiber Adelta, nonhuman, priority journal, rat, somatosensory cortex, tactile stimulation, Animals, Brain Mapping, Electroencephalography, Evoked Potentials, Somatosensory, Lasers, Gas, Male, Nerve Fibers, Myelinated, Neural Conduction, Pain, Pain Measurement, Physical Stimulation, Rats, Rats, Wistar, Reaction Time, Somatosensory Cortex, Tail",
author = "Fu-Shan Jaw and Kao, {Yu-Chieh Jill} and Chih-Ping Chen and Wen-Li Liao",
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year = "2009",
doi = "10.1016/j.neuroscience.2008.09.046",
language = "English",
volume = "158",
pages = "945--950",
journal = "Neuroscience",
issn = "0306-4522",
publisher = "Elsevier Ireland Ltd",
number = "2",
}