Central thalamic deep-brain stimulation alters striatal-thalamic connectivity in cognitive neural behavior

Hui Ching Lin; Han Chi Pan; Sheng Huang Lin; Yu Chun Lo; Elise Ting Hsin Shen; Lun De Liao; Pei Han Liao; Yi Wei Chien; Kuei Da Liao; Fu Shan Jaw; Kai Wen Chu; Hsin Yi Lai; You Yin Chen

doi:10.3389/fncir.2015.00087

Central thalamic deep-brain stimulation alters striatal-thalamic connectivity in cognitive neural behavior

Hui Ching Lin, Han Chi Pan, Sheng Huang Lin, Yu Chun Lo, Elise Ting Hsin Shen, Lun De Liao, Pei Han Liao, Yi Wei Chien, Kuei Da Liao, Fu Shan Jaw, Kai Wen Chu, Hsin Yi Lai, You Yin Chen

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21 Citations (Scopus)

Abstract

Central thalamic deep brain stimulation (CT-DBS) has been proposed as an experimental therapeutic approach to produce consistent sustained regulation of forebrain arousal for several neurological diseases. We investigated local field potentials (LFPs) induced by CT-DBS from the thalamic central lateral nuclei (CL) and the striatum as potential biomarkers for the enhancement of lever-pressing skill learning. LFPs were simultaneously recorded from multiple sites in the CL, ventral striatum (Vstr), and dorsal striatum (Dstr). LFP oscillation power and functional connectivity were assessed and compared between the CT-DBS and sham control groups. The theta and alpha LFP oscillations were significantly increased in the CL and striatum in the CT-DBS group. Furthermore, interhemispheric coherences between bilateral CL and striatum were increased in the theta band. Additionally, enhancement of c-Fos activity, dopamine D2 receptor (Drd2), and α4-nicotinic acetylcholine receptor (α4-nAChR) occurred after CT-DBS treatment in the striatum and hippocampus. CT-DBS strengthened thalamic-striatal functional connectivity, which demonstrates that the inter-regional connectivity enhancement might contribute to synaptic plasticity in the striatum. Altered dopaminergic and cholinergic receptors resulted in modulation of striatal synaptic plasticity's ability to regulate downstream signaling cascades for higher brain functions of lever-pressing skill learning.

Original language	English
Article number	87
Journal	Frontiers in Neural Circuits
Volume	9
Issue number	JAN2016
DOIs	https://doi.org/10.3389/fncir.2015.00087
Publication status	Published - Jan 13 2016
Externally published	Yes

Keywords

Deep brain stimulation
Functional connectivity
Local field potentials
Reward-associated learning
Thalamus

ASJC Scopus subject areas

Neuroscience (miscellaneous)
Sensory Systems
Cognitive Neuroscience
Cellular and Molecular Neuroscience

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10.3389/fncir.2015.00087

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Lin, H. C., Pan, H. C., Lin, S. H., Lo, Y. C., Shen, E. T. H., Liao, L. D., Liao, P. H., Chien, Y. W., Liao, K. D., Jaw, F. S., Chu, K. W., Lai, H. Y., & Chen, Y. Y. (2016). Central thalamic deep-brain stimulation alters striatal-thalamic connectivity in cognitive neural behavior. Frontiers in Neural Circuits, 9(JAN2016), Article 87. https://doi.org/10.3389/fncir.2015.00087

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title = "Central thalamic deep-brain stimulation alters striatal-thalamic connectivity in cognitive neural behavior",

abstract = "Central thalamic deep brain stimulation (CT-DBS) has been proposed as an experimental therapeutic approach to produce consistent sustained regulation of forebrain arousal for several neurological diseases. We investigated local field potentials (LFPs) induced by CT-DBS from the thalamic central lateral nuclei (CL) and the striatum as potential biomarkers for the enhancement of lever-pressing skill learning. LFPs were simultaneously recorded from multiple sites in the CL, ventral striatum (Vstr), and dorsal striatum (Dstr). LFP oscillation power and functional connectivity were assessed and compared between the CT-DBS and sham control groups. The theta and alpha LFP oscillations were significantly increased in the CL and striatum in the CT-DBS group. Furthermore, interhemispheric coherences between bilateral CL and striatum were increased in the theta band. Additionally, enhancement of c-Fos activity, dopamine D2 receptor (Drd2), and α4-nicotinic acetylcholine receptor (α4-nAChR) occurred after CT-DBS treatment in the striatum and hippocampus. CT-DBS strengthened thalamic-striatal functional connectivity, which demonstrates that the inter-regional connectivity enhancement might contribute to synaptic plasticity in the striatum. Altered dopaminergic and cholinergic receptors resulted in modulation of striatal synaptic plasticity's ability to regulate downstream signaling cascades for higher brain functions of lever-pressing skill learning.",

keywords = "Deep brain stimulation, Functional connectivity, Local field potentials, Reward-associated learning, Thalamus",

author = "Lin, {Hui Ching} and Pan, {Han Chi} and Lin, {Sheng Huang} and Lo, {Yu Chun} and Shen, {Elise Ting Hsin} and Liao, {Lun De} and Liao, {Pei Han} and Chien, {Yi Wei} and Liao, {Kuei Da} and Jaw, {Fu Shan} and Chu, {Kai Wen} and Lai, {Hsin Yi} and Chen, {You Yin}",

note = "Publisher Copyright: {\textcopyright} 2016 Lin, Pan, Lin, Lo, Shen, Liao, Liao, Chien, Liao, Jaw, Chu, Lai and Chen.",

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AU - Pan, Han Chi

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AU - Lo, Yu Chun

AU - Shen, Elise Ting Hsin

AU - Liao, Lun De

AU - Liao, Pei Han

AU - Chien, Yi Wei

AU - Liao, Kuei Da

AU - Jaw, Fu Shan

AU - Chu, Kai Wen

AU - Lai, Hsin Yi

AU - Chen, You Yin

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Central thalamic deep-brain stimulation alters striatal-thalamic connectivity in cognitive neural behavior

Abstract

Keywords

ASJC Scopus subject areas

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