Cell-type-dependent associations of heme oxygenase-1 GT-repeat polymorphisms with the cancer risk in arsenic-exposed individuals: A preliminary report

M. M. Wu; W. F. Cheng; L. I. Hsu; C. J. Chen; H. Y. Chiou; T. C. Lee

Cell-type-dependent associations of heme oxygenase-1 GT-repeat polymorphisms with the cancer risk in arsenic-exposed individuals: A preliminary report

M. M. Wu, W. F. Cheng, L. I. Hsu, C. J. Chen, H. Y. Chiou, T. C. Lee

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Heme oxygenase (HO)-1 is highly up-regulated by many stressful stimuli, including arsenic. A GT-repeat polymorphism in the HO-1 gene promoter can inversely modulate the levels of HO-1 induction. Long-term digestion of arsenic-contaminated drinking water may cause cancers of anatomic variety. We carried out this study to examine the correlation of HO-1 GT-repeat polymorphism with cancer risk in arsenic-exposed individuals during a 10-year follow-up. A total of 1,004 participants who had HO-1 genotyping available from two arsenicosis-endemic areas in Taiwan were included. Baseline characteristics derived from questionnaire interview were collected in 1988-1990 for the subjects of the BFD-endemic area and in 1996-1998 the subjects of the Lanyang Basin area. Allelic GT-repeats were categorized into short (S, 150 μg/L-year. Carriers of S/S genotype had a significantly increased risk of non-melanoma skin cancer [HR 3.05 (95% CI, 1.24-7.48), P = 0.015] as compared to those who carried L/L genotype for the entire subjects. Regarding liver and intrahepatic bile ducts cancer, carriers of S/S genotype also had a significantly increased risk [HR 4.14 (95% CI, 1.30-13.21), P = 0.016] when compared to those carried L/S genotype. We provided evidence that HO-1 gene variants may modify the carcinogenic effect of arsenic in a cell-type-dependent pattern.

Original language	English
Title of host publication	One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment
Publisher	CRC Press/Balkema
Pages	519-520
Number of pages	2
ISBN (Print)	9781138001411
Publication status	Published - 2014
Event	5th International Congress on Arsenic in the Environment, As 2014 - Buenos Aires, Argentina Duration: May 11 2014 → May 16 2014

Other

Other	5th International Congress on Arsenic in the Environment, As 2014
Country/Territory	Argentina
City	Buenos Aires
Period	5/11/14 → 5/16/14

ASJC Scopus subject areas

Chemical Health and Safety

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

Wu, M. M., Cheng, W. F., Hsu, L. I., Chen, C. J., Chiou, H. Y., & Lee, T. C. (2014). Cell-type-dependent associations of heme oxygenase-1 GT-repeat polymorphisms with the cancer risk in arsenic-exposed individuals: A preliminary report. In One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment (pp. 519-520). CRC Press/Balkema.

Cell-type-dependent associations of heme oxygenase-1 GT-repeat polymorphisms with the cancer risk in arsenic-exposed individuals: A preliminary report. / Wu, M. M.; Cheng, W. F.; Hsu, L. I. et al.
One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment. CRC Press/Balkema, 2014. p. 519-520.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Wu, MM, Cheng, WF, Hsu, LI, Chen, CJ, Chiou, HY & Lee, TC 2014, Cell-type-dependent associations of heme oxygenase-1 GT-repeat polymorphisms with the cancer risk in arsenic-exposed individuals: A preliminary report. in One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment. CRC Press/Balkema, pp. 519-520, 5th International Congress on Arsenic in the Environment, As 2014, Buenos Aires, Argentina, 5/11/14.

Wu MM, Cheng WF, Hsu LI, Chen CJ, Chiou HY, Lee TC. Cell-type-dependent associations of heme oxygenase-1 GT-repeat polymorphisms with the cancer risk in arsenic-exposed individuals: A preliminary report. In One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment. CRC Press/Balkema. 2014. p. 519-520

Wu, M. M. ; Cheng, W. F. ; Hsu, L. I. et al. / Cell-type-dependent associations of heme oxygenase-1 GT-repeat polymorphisms with the cancer risk in arsenic-exposed individuals : A preliminary report. One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment. CRC Press/Balkema, 2014. pp. 519-520

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abstract = "Heme oxygenase (HO)-1 is highly up-regulated by many stressful stimuli, including arsenic. A GT-repeat polymorphism in the HO-1 gene promoter can inversely modulate the levels of HO-1 induction. Long-term digestion of arsenic-contaminated drinking water may cause cancers of anatomic variety. We carried out this study to examine the correlation of HO-1 GT-repeat polymorphism with cancer risk in arsenic-exposed individuals during a 10-year follow-up. A total of 1,004 participants who had HO-1 genotyping available from two arsenicosis-endemic areas in Taiwan were included. Baseline characteristics derived from questionnaire interview were collected in 1988-1990 for the subjects of the BFD-endemic area and in 1996-1998 the subjects of the Lanyang Basin area. Allelic GT-repeats were categorized into short (S, 150 μg/L-year. Carriers of S/S genotype had a significantly increased risk of non-melanoma skin cancer [HR 3.05 (95% CI, 1.24-7.48), P = 0.015] as compared to those who carried L/L genotype for the entire subjects. Regarding liver and intrahepatic bile ducts cancer, carriers of S/S genotype also had a significantly increased risk [HR 4.14 (95% CI, 1.30-13.21), P = 0.016] when compared to those carried L/S genotype. We provided evidence that HO-1 gene variants may modify the carcinogenic effect of arsenic in a cell-type-dependent pattern.",

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AB - Heme oxygenase (HO)-1 is highly up-regulated by many stressful stimuli, including arsenic. A GT-repeat polymorphism in the HO-1 gene promoter can inversely modulate the levels of HO-1 induction. Long-term digestion of arsenic-contaminated drinking water may cause cancers of anatomic variety. We carried out this study to examine the correlation of HO-1 GT-repeat polymorphism with cancer risk in arsenic-exposed individuals during a 10-year follow-up. A total of 1,004 participants who had HO-1 genotyping available from two arsenicosis-endemic areas in Taiwan were included. Baseline characteristics derived from questionnaire interview were collected in 1988-1990 for the subjects of the BFD-endemic area and in 1996-1998 the subjects of the Lanyang Basin area. Allelic GT-repeats were categorized into short (S, 150 μg/L-year. Carriers of S/S genotype had a significantly increased risk of non-melanoma skin cancer [HR 3.05 (95% CI, 1.24-7.48), P = 0.015] as compared to those who carried L/L genotype for the entire subjects. Regarding liver and intrahepatic bile ducts cancer, carriers of S/S genotype also had a significantly increased risk [HR 4.14 (95% CI, 1.30-13.21), P = 0.016] when compared to those carried L/S genotype. We provided evidence that HO-1 gene variants may modify the carcinogenic effect of arsenic in a cell-type-dependent pattern.

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Cell-type-dependent associations of heme oxygenase-1 GT-repeat polymorphisms with the cancer risk in arsenic-exposed individuals: A preliminary report

Abstract

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ASJC Scopus subject areas

UN SDGs

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