Abstract
The nanostructure of a biomaterial surface has strong influence on cell behavior. The migration of cells on nanostructured surfaces, however, has not been investigated so far. In this study, we used PCL/PEG diblock copolymers as model surfaces to examine the effect of nanoislands on migration of different cells, including fibroblasts and endothelial cells. The water sliding angle of the substrates was measured. The cell migration rate was examined under a real-time optical microscope. It was found that a greater cell migration rate correlated with the smaller sliding angle of the substrate.
Original language | English |
---|---|
Pages (from-to) | 482-490 |
Number of pages | 9 |
Journal | Macromolecular Bioscience |
Volume | 7 |
Issue number | 4 |
DOIs | |
Publication status | Published - Apr 10 2007 |
Externally published | Yes |
Keywords
- Cell migration
- Microphase separation
- Nanotopography
- PCL/PEG diblock copolymer
- Sliding angle
ASJC Scopus subject areas
- Biotechnology
- Bioengineering
- Biomaterials
- Polymers and Plastics
- Materials Chemistry