CD8+CD122+ T cell homeostasis is controlled by different levels of IL-15 trans-presentation

Gilbert Aaron Lee; Nan Shih Liao

doi:10.1016/j.jmii.2020.06.005

CD8⁺CD122⁺ T cell homeostasis is controlled by different levels of IL-15 trans-presentation

Research output: Contribution to journal › Article › peer-review

Abstract

The homeostasis of CD8⁺CD122⁺ T cell requires IL-15 trans-presentation. We use Il15ra mutant mice and bone marrow chimeras to assess the role of IL-15 trans-presentation level in CD8⁺CD122⁺ T cells homeostasis. We demonstrate that CD8⁺CD122⁺ T cells require different levels of IL-15 trans-presentation to support their homeostasis.

Original language	English
Pages (from-to)	514-517
Number of pages	4
Journal	Journal of Microbiology, Immunology and Infection
Volume	54
Issue number	3
DOIs	https://doi.org/10.1016/j.jmii.2020.06.005
Publication status	Published - Jun 2021

Keywords

CD8CD122 T cell homeostasis
IL-15

ASJC Scopus subject areas

Immunology and Allergy
General Immunology and Microbiology
Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.jmii.2020.06.005

Cite this

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title = "CD8+CD122+ T cell homeostasis is controlled by different levels of IL-15 trans-presentation",

abstract = "The homeostasis of CD8+CD122+ T cell requires IL-15 trans-presentation. We use Il15ra mutant mice and bone marrow chimeras to assess the role of IL-15 trans-presentation level in CD8+CD122+ T cells homeostasis. We demonstrate that CD8+CD122+ T cells require different levels of IL-15 trans-presentation to support their homeostasis.",

keywords = "CD8CD122 T cell homeostasis, IL-15",

author = "Lee, {Gilbert Aaron} and Liao, {Nan Shih}",

note = "Funding Information: This work was supported by Academia Sinica ( 20-2d ) and Taipei Medical University Hospital ( 107TMUH SP-01 ). Publisher Copyright: {\textcopyright} 2020 Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2021",

month = jun,

doi = "10.1016/j.jmii.2020.06.005",

language = "English",

volume = "54",

pages = "514--517",

journal = "Journal of Microbiology, Immunology and Infection",

issn = "1684-1182",

publisher = "Lippincott Williams & Wilkins Asia",

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AU - Lee, Gilbert Aaron

AU - Liao, Nan Shih

N1 - Funding Information: This work was supported by Academia Sinica ( 20-2d ) and Taipei Medical University Hospital ( 107TMUH SP-01 ). Publisher Copyright: © 2020 Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2021/6

Y1 - 2021/6

N2 - The homeostasis of CD8+CD122+ T cell requires IL-15 trans-presentation. We use Il15ra mutant mice and bone marrow chimeras to assess the role of IL-15 trans-presentation level in CD8+CD122+ T cells homeostasis. We demonstrate that CD8+CD122+ T cells require different levels of IL-15 trans-presentation to support their homeostasis.

AB - The homeostasis of CD8+CD122+ T cell requires IL-15 trans-presentation. We use Il15ra mutant mice and bone marrow chimeras to assess the role of IL-15 trans-presentation level in CD8+CD122+ T cells homeostasis. We demonstrate that CD8+CD122+ T cells require different levels of IL-15 trans-presentation to support their homeostasis.

KW - CD8CD122 T cell homeostasis

KW - IL-15

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