TY - JOUR
T1 - CD14 promoter polymorphism in Chinese alcoholic patients with cirrhosis of liver and acute pancreatitis
AU - Chao, You-Chen
AU - Chu, Heng-Cheng
AU - Chang, Wei-Kuo
AU - Huang, Hsin-Hung
AU - Hsieh, Tsai-Yuan
N1 - 被引用次數：15
Export Date: 22 March 2016
CODEN: WJGAF
通訊地址: Chao, Y.-C.No. 325 Section 2, Cheng-Kung Road, Neihu 114 Taipei, Taiwan; 電子郵件： [email protected]
化學物質/CAS: Antigens, CD14; DNA, 9007-49-2
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PY - 2005
Y1 - 2005
N2 - Aim: To investigate the relationship between genetic polymorphism of the CD14 promoter and the occurrence of alcoholic cirrhosis and alcoholic pancreatitis, and to challenge the conclusion made earlier that the patients with acute alcoholic pancreatitis and patients with alcoholic cirrhosis of liver are two different subpopulations. Methods: Using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method, we determined the polymorphism of CD14 gene and aldehyde dehydrogenase gene 2 (ALDH 2) in 335 alcoholic patients with different organ complications i.e., cirrhosis of liver (n = 100), acute pancreatitis (n = 100), esophageal cancer (n = 82) and avascular necrosis of hip joint (AVN) (n = 53) and 194 non-alcoholic controls in a Chinese group. Results: The results showed that the carriage of T allele was not different among alcoholic patients with cirrhosis of liver, alcoholic patients with other complication and non-alcoholic controls. On the other hand, the carriage of the C allele was significantly more prevalent for alcoholic pancreatitis than for esophageal cancer (0.79 vs 0.60, P
AB - Aim: To investigate the relationship between genetic polymorphism of the CD14 promoter and the occurrence of alcoholic cirrhosis and alcoholic pancreatitis, and to challenge the conclusion made earlier that the patients with acute alcoholic pancreatitis and patients with alcoholic cirrhosis of liver are two different subpopulations. Methods: Using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method, we determined the polymorphism of CD14 gene and aldehyde dehydrogenase gene 2 (ALDH 2) in 335 alcoholic patients with different organ complications i.e., cirrhosis of liver (n = 100), acute pancreatitis (n = 100), esophageal cancer (n = 82) and avascular necrosis of hip joint (AVN) (n = 53) and 194 non-alcoholic controls in a Chinese group. Results: The results showed that the carriage of T allele was not different among alcoholic patients with cirrhosis of liver, alcoholic patients with other complication and non-alcoholic controls. On the other hand, the carriage of the C allele was significantly more prevalent for alcoholic pancreatitis than for esophageal cancer (0.79 vs 0.60, P
KW - Alcoholic patients
KW - CD14 promoter
KW - Polymorphism
KW - aldehyde dehydrogenase isoenzyme 2
KW - CD14 antigen
KW - adult
KW - alcohol liver cirrhosis
KW - alcoholic pancreatitis
KW - article
KW - avascular necrosis
KW - Chinese
KW - controlled study
KW - DNA polymorphism
KW - esophagus cancer
KW - female
KW - gene frequency
KW - genotype
KW - heterozygote
KW - human
KW - major clinical study
KW - male
KW - pathogenesis
KW - polymerase chain reaction
KW - prevalence
KW - promoter region
KW - restriction fragment length polymorphism
KW - statistical analysis
KW - Adult
KW - Aged
KW - Antigens, CD14
KW - Asian Continental Ancestry Group
KW - Base Sequence
KW - Case-Control Studies
KW - DNA
KW - Female
KW - Humans
KW - Liver Cirrhosis, Alcoholic
KW - Male
KW - Middle Aged
KW - Pancreatitis, Alcoholic
KW - Polymorphism, Genetic
KW - Promoter Regions (Genetics)
KW - Taiwan
M3 - Article
SN - 1007-9327
VL - 11
SP - 6043
EP - 6048
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
IS - 38
ER -
