Carvedilol modulates the expression of hypoxia-inducible factor-1α and vascular endothelial growth factor in a rat model of volume-overload heart failure

Kou-Gi Shyu; Ming Jen Lu; Hang Chang; Hsien Yi Sun; Bao Wei Wang; Peiliang Kuan

doi:10.1016/j.cardfail.2004.06.433

Carvedilol modulates the expression of hypoxia-inducible factor-1α and vascular endothelial growth factor in a rat model of volume-overload heart failure

Kou-Gi Shyu, Ming Jen Lu, Hang Chang, Hsien Yi Sun, Bao Wei Wang, Peiliang Kuan

Graduate Institute of Medical Sciences

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

Background: The use of β-blockers has emerged as a beneficial treatment for congestive heart failure. Hypoxia-inducible factor-1α (HIF-1α) is tightly regulated in the ventricular myocardium. However, the expression of HIF-1α in chronic heart failure resulting from volume overload and after treatment with β-blocker is little known. Methods and Results: To test the hypothesis that HIF-1α plays a role in the failing myocardium because of volume overload, an aorta-caval shunt was created for 4 weeks in adult Sprague-Dawley rats to induce volume-overload heart failure. Carvedilol at 50 mg/kg body weight per day after surgery was given. The heart weight and body weight ratio increased from 2.6 ± 0.3 in the sham group to 3.9 ± 0.7 (P

Original language	English
Pages (from-to)	152-159
Number of pages	8
Journal	Journal of Cardiac Failure
Volume	11
Issue number	2
DOIs	https://doi.org/10.1016/j.cardfail.2004.06.433
Publication status	Published - Mar 2005

Keywords

Congestive heart failure
Gene expression
Growth factor
β-blocker

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

Access to Document

10.1016/j.cardfail.2004.06.433

Cite this

@article{9e6f83798c1142a19af4a076c20cc8a6,

title = "Carvedilol modulates the expression of hypoxia-inducible factor-1α and vascular endothelial growth factor in a rat model of volume-overload heart failure",

abstract = "Background: The use of β-blockers has emerged as a beneficial treatment for congestive heart failure. Hypoxia-inducible factor-1α (HIF-1α) is tightly regulated in the ventricular myocardium. However, the expression of HIF-1α in chronic heart failure resulting from volume overload and after treatment with β-blocker is little known. Methods and Results: To test the hypothesis that HIF-1α plays a role in the failing myocardium because of volume overload, an aorta-caval shunt was created for 4 weeks in adult Sprague-Dawley rats to induce volume-overload heart failure. Carvedilol at 50 mg/kg body weight per day after surgery was given. The heart weight and body weight ratio increased from 2.6 ± 0.3 in the sham group to 3.9 ± 0.7 (P ",

keywords = "Congestive heart failure, Gene expression, Growth factor, β-blocker",

author = "Kou-Gi Shyu and Lu, {Ming Jen} and Hang Chang and Sun, {Hsien Yi} and Wang, {Bao Wei} and Peiliang Kuan",

year = "2005",

month = mar,

doi = "10.1016/j.cardfail.2004.06.433",

language = "English",

volume = "11",

pages = "152--159",

journal = "Journal of Cardiac Failure",

issn = "1071-9164",

publisher = "Elsevier B.V.",

number = "2",

}

TY - JOUR

T1 - Carvedilol modulates the expression of hypoxia-inducible factor-1α and vascular endothelial growth factor in a rat model of volume-overload heart failure

AU - Shyu, Kou-Gi

AU - Lu, Ming Jen

AU - Chang, Hang

AU - Sun, Hsien Yi

AU - Wang, Bao Wei

AU - Kuan, Peiliang

PY - 2005/3

Y1 - 2005/3

N2 - Background: The use of β-blockers has emerged as a beneficial treatment for congestive heart failure. Hypoxia-inducible factor-1α (HIF-1α) is tightly regulated in the ventricular myocardium. However, the expression of HIF-1α in chronic heart failure resulting from volume overload and after treatment with β-blocker is little known. Methods and Results: To test the hypothesis that HIF-1α plays a role in the failing myocardium because of volume overload, an aorta-caval shunt was created for 4 weeks in adult Sprague-Dawley rats to induce volume-overload heart failure. Carvedilol at 50 mg/kg body weight per day after surgery was given. The heart weight and body weight ratio increased from 2.6 ± 0.3 in the sham group to 3.9 ± 0.7 (P

AB - Background: The use of β-blockers has emerged as a beneficial treatment for congestive heart failure. Hypoxia-inducible factor-1α (HIF-1α) is tightly regulated in the ventricular myocardium. However, the expression of HIF-1α in chronic heart failure resulting from volume overload and after treatment with β-blocker is little known. Methods and Results: To test the hypothesis that HIF-1α plays a role in the failing myocardium because of volume overload, an aorta-caval shunt was created for 4 weeks in adult Sprague-Dawley rats to induce volume-overload heart failure. Carvedilol at 50 mg/kg body weight per day after surgery was given. The heart weight and body weight ratio increased from 2.6 ± 0.3 in the sham group to 3.9 ± 0.7 (P

KW - Congestive heart failure

KW - Gene expression

KW - Growth factor

KW - β-blocker

UR - http://www.scopus.com/inward/record.url?scp=13944284587&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=13944284587&partnerID=8YFLogxK

U2 - 10.1016/j.cardfail.2004.06.433

DO - 10.1016/j.cardfail.2004.06.433

M3 - Article

C2 - 15732037

AN - SCOPUS:13944284587

SN - 1071-9164

VL - 11

SP - 152

EP - 159

JO - Journal of Cardiac Failure

JF - Journal of Cardiac Failure

IS - 2

ER -

Carvedilol modulates the expression of hypoxia-inducible factor-1α and vascular endothelial growth factor in a rat model of volume-overload heart failure

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this