Cartilage oligomeric matrix protein overexpression is an independent poor prognostic indicator in patients with intrahepatic cholangiocarcinoma

Khaa Hoo Ong, Yao Yu Hsieh, Hong Yue Lai, Ding Ping Sun, Tzu Ju Chen, Steven Kuan Hua Huang, Yu Feng Tian, Chia Ling Chou, Yow Ling Shiue, Hung Chang Wu, Ti Chun Chan, Hsin Hwa Tsai, Chien Feng Li, Po An Su, Yu Hsuan Kuo

Research output: Contribution to journalArticlepeer-review

Abstract

Cartilage oligomeric matrix protein (COMP) interacts with various extracellular matrix proteins in tissues. Elevated COMP levels recently linked to worse overall survival in multiple cancer types. COMP's significance in intrahepatic cholangiocarcinoma (iCCA) remains uncertain. Here we report a retrospective study to explore COMP's impact on iCCA outcomes. We collected 182 patients' iCCA tumor tissues. COMP overexpression was associated with adverse factors like R1 resection (p = 0.008), advanced T stage (p < 0.001), large duct type (p = 0.004), and poorly differentiated histology (p = 0.002). COMP overexpression correlates with poorer DFS (HR, 3.651; p = 0.001), OS (HR, 1.827; p = 0.023), LRFS (HR, 4.077; p < 0.001), and MFS (HR, 3.718; p < 0.001). High COMP expression ties to worse overall survival (p = 0.0001), DSS (p < 0.0001), LRFS (p < 0.0001), and MFS (p < 0.0001). In conclusion, COMP overexpression links to poor prognosis and pathological features in iCCA, indicating its potential as a biomarker.

Original languageEnglish
Article number17444
JournalScientific Reports
Volume13
Issue number1
DOIs
Publication statusPublished - Dec 2023

ASJC Scopus subject areas

  • General

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