TY - JOUR
T1 - Cardiovascular Pharmacological Actions of Rutaecarpine, a Quinazolinocarboline Alkaloid Isolated From Evodia rutaecarpa
AU - Jayakumar, Thanasekaran
AU - Sheu, Joen Rong
PY - 2011/4
Y1 - 2011/4
N2 - Evodia rutaecarpa (Chinese name: Wu-Chu-Yu) is a well-known traditional Chinese medicine and has long been used in Chinese medical practice. Rutaecarpine is an indolopyridoquinazolinone alkaloid isolated from E. rutaecarpa and related herbs, which has been shown to have cardiovascular biological effects, such as inotropic and chronotropic, vasorelaxant, antiplatelet aggregation, and anti-inflammatory effects. Furthermore, it has been reported that rutaecarpine has beneficial effects on some cardiovascular diseases. This review was undertaken to summarize data on the cardiovascular pharmacological actions of rutaecarpine published over the recent years, aiming to provide more evidence supporting its use in the treatment of cardiovascular diseases. This review also reveals some interesting and unique pharmacological properties, which may explain its vascular and platelet effects.
AB - Evodia rutaecarpa (Chinese name: Wu-Chu-Yu) is a well-known traditional Chinese medicine and has long been used in Chinese medical practice. Rutaecarpine is an indolopyridoquinazolinone alkaloid isolated from E. rutaecarpa and related herbs, which has been shown to have cardiovascular biological effects, such as inotropic and chronotropic, vasorelaxant, antiplatelet aggregation, and anti-inflammatory effects. Furthermore, it has been reported that rutaecarpine has beneficial effects on some cardiovascular diseases. This review was undertaken to summarize data on the cardiovascular pharmacological actions of rutaecarpine published over the recent years, aiming to provide more evidence supporting its use in the treatment of cardiovascular diseases. This review also reveals some interesting and unique pharmacological properties, which may explain its vascular and platelet effects.
KW - Platelets aggregation
KW - Rutaecarpine
KW - Thrombosis
KW - Uterotonia
KW - Vasodilation
UR - http://www.scopus.com/inward/record.url?scp=79954819918&partnerID=8YFLogxK
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U2 - 10.1016/j.jecm.2011.02.004
DO - 10.1016/j.jecm.2011.02.004
M3 - Review article
AN - SCOPUS:79954819918
SN - 1878-3317
VL - 3
SP - 63
EP - 69
JO - Journal of Experimental and Clinical Medicine
JF - Journal of Experimental and Clinical Medicine
IS - 2
ER -
