Cardiovascular autonomic neuropathy, autonomic symptoms and diabetic complications in 674 type 2 diabetes

Hung Ta Chen, Hong Da Lin, Justin G.S. Won, Chen Hsen Lee, Shiao Chi Wu, Jiun Dian Lin, Li Ying Juan, Low Tone Ho, Kam Tsun Tang

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


Aims: To determine the relationships between cardiovascular autonomic neuropathy (CAN) and autonomic symptoms, clinical parameters and diabetic complications in type 2 diabetes (T2DM). Methods: The results of autonomic symptoms, clinical parameters, diabetes complications and cardiovascular reflex (CVR) tests of 674 T2DM were analyzed. Results: Significant correlations were found between CAN risk and age (p = 0.019), duration of diabetes (p = 0.008), HbA1c (p < 0.001), systolic blood pressure (p = 0.006), nephropathy (p < 0.001), retinopathy (p < 0.001), and QTc interval (p < 0.001), but not BMI and hyperlipidemia. Patients with retinopathy or proteinuria had increase risk of CAN, and proliferative diabetic retinopathy (PDR) was the most significant risk factor (odds ratio: 6.85; 95% CI: 2.32-20.20) for CAN. Eighty-three percent of patients complained of autonomic symptoms; and the more symptoms complained, the higher the prevalence of CAN. Impotence was the only single symptom associated with CAN risk. Additional CAN risks were also observed when patients with multiple symptoms and/or complications in combinations. Conclusions: Our results implied that patients with multiple symptoms and/or complications in combinations have increased CAN risk, and this may provide additional information for clinicians to identify T2DM at risk of having CAN.

Original languageEnglish
Pages (from-to)282-290
Number of pages9
JournalDiabetes Research and Clinical Practice
Issue number2
Publication statusPublished - Nov 2008
Externally publishedYes


  • Autonomic symptoms
  • Cardiovascular autonomic neuropathy
  • Cardiovascular reflex test
  • Diabetic nephropathy
  • Diabetic retinopathy

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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