Cardiac nucleotide levels and mitochondrial respiration in copper-deficient rats

Jane C.J. Chao; Denis M. Medeiros; Ruth A. Altschuld; Charlene M. Hohl

doi:10.1016/0300-9629(93)90024-X

Cardiac nucleotide levels and mitochondrial respiration in copper-deficient rats

Jane C.J. Chao, Denis M. Medeiros, Ruth A. Altschuld, Charlene M. Hohl

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

1. 1. Male weanling Long-Evans rats were randomly assigned to either copper-adequate (6.0 mgCu/kg feed) or copper-deficient (<1.0 mg Cu/kg feed) diets for a 5 week period. 2. 2. Cardiac ATP levels and energy charges did not differ between the two groups. Levels of NAD and phosphocreatine as well as the sum of pyridine nucleotides were greater in copper-deficient rats compared with copper-adequate rats using HPLC analysis. 3. 3. Mitochondrial respiratory control ratios and oxygen consumption rates from copper-deficient rat hearts were depressed, although ADP:O ratios were similar to copper-adequate rat hearts.

Original language	English
Pages (from-to)	163-168
Number of pages	6
Journal	Comparative Biochemistry and Physiology -- Part A: Physiology
Volume	104
Issue number	1
DOIs	https://doi.org/10.1016/0300-9629(93)90024-X
Publication status	Published - Jan 1993
Externally published	Yes

ASJC Scopus subject areas

Physiology

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AU - Altschuld, Ruth A.

AU - Hohl, Charlene M.

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N2 - 1. 1. Male weanling Long-Evans rats were randomly assigned to either copper-adequate (6.0 mgCu/kg feed) or copper-deficient (<1.0 mg Cu/kg feed) diets for a 5 week period. 2. 2. Cardiac ATP levels and energy charges did not differ between the two groups. Levels of NAD and phosphocreatine as well as the sum of pyridine nucleotides were greater in copper-deficient rats compared with copper-adequate rats using HPLC analysis. 3. 3. Mitochondrial respiratory control ratios and oxygen consumption rates from copper-deficient rat hearts were depressed, although ADP:O ratios were similar to copper-adequate rat hearts.

AB - 1. 1. Male weanling Long-Evans rats were randomly assigned to either copper-adequate (6.0 mgCu/kg feed) or copper-deficient (<1.0 mg Cu/kg feed) diets for a 5 week period. 2. 2. Cardiac ATP levels and energy charges did not differ between the two groups. Levels of NAD and phosphocreatine as well as the sum of pyridine nucleotides were greater in copper-deficient rats compared with copper-adequate rats using HPLC analysis. 3. 3. Mitochondrial respiratory control ratios and oxygen consumption rates from copper-deficient rat hearts were depressed, although ADP:O ratios were similar to copper-adequate rat hearts.

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Cardiac nucleotide levels and mitochondrial respiration in copper-deficient rats

Abstract

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