TY - JOUR
T1 - Cardiac Involvement of COVID-19
T2 - A Comprehensive Review
AU - Chang, Wei Ting
AU - Toh, Han Siong
AU - Liao, Chia Te
AU - Yu, Wen Liang
N1 - Publisher Copyright:
© 2020 Southern Society for Clinical Investigation
PY - 2021/1
Y1 - 2021/1
N2 - Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus. SARS-CoV-2 caused COVID-19 has reached a pandemic level. COVID-19 can significantly affect patients’ cardiovascular systems. First, those with COVID-19 and preexisting cardiovascular disease have an increased risk of severe disease and death. Mortality from COVID-19 is strongly associated with cardiovascular disease, diabetes, and hypertension. Second, therapies under investigation for COVID-19 may have cardiovascular side effects of arrhythmia. Third, COVID-19 is associated with multiple direct and indirect cardiovascular complications. Associated with a high inflammatory burden related to cytokine release, COVID-19 can induce vascular inflammation, acute myocardial injury, myocarditis, arrhythmias, venous thromboembolism, metabolic syndrome and Kawasaki disease. Understanding the effects of COVID-19 on the cardiovascular system is essential for providing comprehensive medical care for cardiac and/or COVID-19 patients. We hereby review the literature on COVID-19 regarding cardiovascular virus involvement.
AB - Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus. SARS-CoV-2 caused COVID-19 has reached a pandemic level. COVID-19 can significantly affect patients’ cardiovascular systems. First, those with COVID-19 and preexisting cardiovascular disease have an increased risk of severe disease and death. Mortality from COVID-19 is strongly associated with cardiovascular disease, diabetes, and hypertension. Second, therapies under investigation for COVID-19 may have cardiovascular side effects of arrhythmia. Third, COVID-19 is associated with multiple direct and indirect cardiovascular complications. Associated with a high inflammatory burden related to cytokine release, COVID-19 can induce vascular inflammation, acute myocardial injury, myocarditis, arrhythmias, venous thromboembolism, metabolic syndrome and Kawasaki disease. Understanding the effects of COVID-19 on the cardiovascular system is essential for providing comprehensive medical care for cardiac and/or COVID-19 patients. We hereby review the literature on COVID-19 regarding cardiovascular virus involvement.
KW - Coronavirus
KW - Covid-19
KW - Myocardial injury
KW - myocarditis
KW - Sars-cov-2
UR - http://www.scopus.com/inward/record.url?scp=85095946193&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85095946193&partnerID=8YFLogxK
U2 - 10.1016/j.amjms.2020.10.002
DO - 10.1016/j.amjms.2020.10.002
M3 - Review article
C2 - 33187633
AN - SCOPUS:85095946193
SN - 0002-9629
VL - 361
SP - 14
EP - 22
JO - American Journal of the Medical Sciences
JF - American Journal of the Medical Sciences
IS - 1
ER -
