Cardiac Involvement of COVID-19: A Comprehensive Review

Wei Ting Chang, Han Siong Toh, Chia Te Liao, Wen Liang Yu

Research output: Contribution to journalReview articlepeer-review

75 Citations (Scopus)


Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus. SARS-CoV-2 caused COVID-19 has reached a pandemic level. COVID-19 can significantly affect patients’ cardiovascular systems. First, those with COVID-19 and preexisting cardiovascular disease have an increased risk of severe disease and death. Mortality from COVID-19 is strongly associated with cardiovascular disease, diabetes, and hypertension. Second, therapies under investigation for COVID-19 may have cardiovascular side effects of arrhythmia. Third, COVID-19 is associated with multiple direct and indirect cardiovascular complications. Associated with a high inflammatory burden related to cytokine release, COVID-19 can induce vascular inflammation, acute myocardial injury, myocarditis, arrhythmias, venous thromboembolism, metabolic syndrome and Kawasaki disease. Understanding the effects of COVID-19 on the cardiovascular system is essential for providing comprehensive medical care for cardiac and/or COVID-19 patients. We hereby review the literature on COVID-19 regarding cardiovascular virus involvement.

Original languageEnglish
Pages (from-to)14-22
Number of pages9
JournalAmerican Journal of the Medical Sciences
Issue number1
Publication statusPublished - Jan 2021


  • Coronavirus
  • Covid-19
  • Myocardial injury
  • myocarditis
  • Sars-cov-2

ASJC Scopus subject areas

  • Medicine(all)


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