Cardiac autonomic dysregulation in patients with acute hepatitis

Kuan Yang Chen, Chien Lin Chen, Cheryl C H Yang, Terry B J Kuo

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


BACKGROUND: Autonomic dysfunction is common in patients with chronic liver disease, but it is still unclear whether acute hepatitis coincides with alterations in autonomic functions. METHODS: We evaluated the heart rate variability (HRV) of 10 patients with acute hepatitis (6 males, 4 females; mean age, 44.0 y; range, 20-69 y). Frequency-domain analysis of short-term and stationary R-R intervals was performed on the first day of admission to detect low-frequency power (LF; 0.04-0.15 Hz), high-frequency power (HF, 0.15-0.40 Hz), the ratio of LF to HF (LF/HF), and LF in normalized units (LF%). The same measurement was repeated on the 7th day of admission. RESULTS: We found that there was a significant increase of HF as well as variance of the R-R interval on the 7th day after admission (P < 0.05). There was a significant negative correlation between HF and the change of total bilirubin (P < 0.05). CONCLUSIONS: The study demonstrates a change in cardiac vagal tone associated with acute hepatitis by analysis of HRV, and such alteration is less pronounced later during the clinical course of acute hepatitis.

Original languageEnglish
Pages (from-to)164-167
Number of pages4
JournalAmerican Journal of the Medical Sciences
Issue number4
Publication statusPublished - Oct 2006
Externally publishedYes


  • Acute hepatitis
  • Heart rate variability
  • Power spectral analysis

ASJC Scopus subject areas

  • General Medicine


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