TY - JOUR
T1 - Cardiac autonomic dysregulation in patients with acute hepatitis
AU - Chen, Kuan Yang
AU - Chen, Chien Lin
AU - Yang, Cheryl C H
AU - Kuo, Terry B J
PY - 2006/10
Y1 - 2006/10
N2 - BACKGROUND: Autonomic dysfunction is common in patients with chronic liver disease, but it is still unclear whether acute hepatitis coincides with alterations in autonomic functions. METHODS: We evaluated the heart rate variability (HRV) of 10 patients with acute hepatitis (6 males, 4 females; mean age, 44.0 y; range, 20-69 y). Frequency-domain analysis of short-term and stationary R-R intervals was performed on the first day of admission to detect low-frequency power (LF; 0.04-0.15 Hz), high-frequency power (HF, 0.15-0.40 Hz), the ratio of LF to HF (LF/HF), and LF in normalized units (LF%). The same measurement was repeated on the 7th day of admission. RESULTS: We found that there was a significant increase of HF as well as variance of the R-R interval on the 7th day after admission (P < 0.05). There was a significant negative correlation between HF and the change of total bilirubin (P < 0.05). CONCLUSIONS: The study demonstrates a change in cardiac vagal tone associated with acute hepatitis by analysis of HRV, and such alteration is less pronounced later during the clinical course of acute hepatitis.
AB - BACKGROUND: Autonomic dysfunction is common in patients with chronic liver disease, but it is still unclear whether acute hepatitis coincides with alterations in autonomic functions. METHODS: We evaluated the heart rate variability (HRV) of 10 patients with acute hepatitis (6 males, 4 females; mean age, 44.0 y; range, 20-69 y). Frequency-domain analysis of short-term and stationary R-R intervals was performed on the first day of admission to detect low-frequency power (LF; 0.04-0.15 Hz), high-frequency power (HF, 0.15-0.40 Hz), the ratio of LF to HF (LF/HF), and LF in normalized units (LF%). The same measurement was repeated on the 7th day of admission. RESULTS: We found that there was a significant increase of HF as well as variance of the R-R interval on the 7th day after admission (P < 0.05). There was a significant negative correlation between HF and the change of total bilirubin (P < 0.05). CONCLUSIONS: The study demonstrates a change in cardiac vagal tone associated with acute hepatitis by analysis of HRV, and such alteration is less pronounced later during the clinical course of acute hepatitis.
KW - Acute hepatitis
KW - Heart rate variability
KW - Power spectral analysis
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U2 - 10.1097/00000441-200610000-00002
DO - 10.1097/00000441-200610000-00002
M3 - Article
C2 - 17031240
AN - SCOPUS:33749823143
SN - 0002-9629
VL - 332
SP - 164
EP - 167
JO - American Journal of the Medical Sciences
JF - American Journal of the Medical Sciences
IS - 4
ER -