Carboxyfullerene decorated titanium dioxide nanomaterials for reactive oxygen species scavenging activities

Kai Cheng Yang, Jia Huei Zheng, Yen Ling Chen, Kuen Chan Lee, Er Chieh Cho

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Titanium dioxide nanomaterials offer superior protection for human skin against ultraviolet light. However, some reports have indicated that they might be associated with adverse effects such as cytotoxicity or reactive oxygen species (ROS) under UV-irradiation due to their nanoscale size. The surfaces of fullerenes are covered with π electrons, constituting aromatic structures, which can effectively scavenge large amounts of radicals. Unfortunately, their poor solubility in water, severe aggregation, and toxicity in biological applications when dispersed in solvent have imposed limitations on the use of fullerenes. Herein, we used carboxyfullerene as a radical scavenger to improve poor solubility. The modified materials were prepared through the esterification of C70-COOH with TNR (TNR/C70-COOH) and P25 (P25/C70-COOH). The structures and the properties were analyzed by using X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS) and high-resolution transmission electron microscopy (HRTEM). In order to investigate the scavenging radical abilities of TiO2 composites, pyridoxine (Vit. B6), nitroblue tetrazolium (NBT) and terephthalic acid (TA) were chosen to react with singlet oxygen, superoxide ions and hydroxyl radicals, respectively. The results show that both types of TiO2 composites could reduce the ROS in the environment and exhibit great potential in anti-oxidative and anti-inflammation applications.

Original languageEnglish
Pages (from-to)53025-53033
Number of pages9
JournalRSC Advances
Issue number58
Publication statusPublished - 2016

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Chemistry(all)


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