Carbon disulfide encephalopathy: Cerebral microangiopathy

Wen Li Chuang, Chin Chang Huang, Chi Jen Chen, Yu Chen Hsieh, Hung Chou Kuo, Tung Sheng Shih

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


To understand cerebral blood circulation after long-term exposure to carbon disulfide (CS2), four patients with encephalopathy and polyneuropathy, who had worked in a viscose rayon plant, were studied. Clinical and laboratory examinations, including brain magnetic resonance images (MRI), computed tomography (CT), CT perfusion, and CT angiography, were carried out. Brain CT and MRI disclosed mild cortical atrophy in all four patients, and multiple lesions in the subcortical white matter, and basal ganglia in three patients. Brain CT angiography and perfusion revealed a statistically significant decrease of cerebral blood flow (CBF) in the total brain parenchyma and basal ganglia, and a decrease of the cerebral blood volume (CBV) in the basal ganglia and a prolonged mean transit time (MTT) in the total brain parenchyma, and the territories of the internal carotid artery (ICA), basal ganglia and occipital lobe. In conclusion, the decrease of CBV and CBF, and the prolonged MTT in the total brain parenchyma, ICA, basal ganglia and occipital lobes, indicated a microangiopathy in patients with CS2 encephalopathy.

Original languageEnglish
Pages (from-to)387-393
Number of pages7
Issue number2
Publication statusPublished - Mar 2007
Externally publishedYes


  • CT angiography
  • CT perfusion
  • Carbon disulfide
  • Microangiopathy
  • Neurotoxic disease

ASJC Scopus subject areas

  • General Neuroscience
  • Toxicology


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