Capsaicin and nonivamide as novel skin permeation enhancers for indomethacin

Jia You Fang, Chia Lang Fang, Chi Tzong Hong, Hsiang Yin Chen, Tzu Ying Lin, Hsiu Mei Wei

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)


The study was conducted in vitro to investigate the changes of indomethacin transdermal permeation pretreated by capsaicin and nonivamide, two compounds chemically similar to Azone. The combined effect of low frequency ultrasound (20 kHz) and enhancers on the indomethacin permeation was also evaluated. The experimental data demonstrated that capsaicin and nonivamide significantly enhanced the flux of indomethacin across nude mouse skin. Enhancement effects of both analogues were very similar and depended predominantly on the concentration tested. Histological examination coupled with visual scores indicated the safety of capsaicin and nonivamide on skin structure. Simultaneous application of ultrasound and enhancers significantly increased skin permeation of indomethacin compared with either ultrasound or enhancers alone. Better effect was obtained by the combination with capsaicin than nonivamide. (C) 2001 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)195-203
Number of pages9
JournalEuropean Journal of Pharmaceutical Sciences
Issue number3
Publication statusPublished - 2000


  • Capsaicin
  • Enhancer
  • Indomethacin
  • Nonivamide
  • Skin permeation
  • Ultrasound

ASJC Scopus subject areas

  • Pharmaceutical Science


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