Capnesterones A and B, new steroids isolated from the soft coral Capnella imbricata

Ting Yu Cheng; Chia Jung Yang; Po Jen Chen; Yu Li Chen; Bo Rong Peng; Te An Kung; Zhi Hong Wen; Kuei Hung Lai; Hsu Ming Chung

doi:10.1016/j.phytol.2024.03.015

Capnesterones A and B, new steroids isolated from the soft coral Capnella imbricata

Ting Yu Cheng, Chia Jung Yang, Po Jen Chen, Yu Li Chen, Bo Rong Peng, Te An Kung, Zhi Hong Wen, Kuei Hung Lai, Hsu Ming Chung

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Two new non-withanolidal steroids with a cross-conjugated dienone structural unit in ring A, capnesterones A (1) and B (2), were isolated from the soft coral Capnella imbricata in the southeast waters of Taiwan. The compounds' structures were elucidated through a comprehensive analysis of spectroscopic data, including IR, ESIMS, ¹H NMR, and ¹³C NMR, and through comparison with previous literature. At a concentration of 10 μM, steroids 1 and 2 exhibited reductions in iNOS levels (60 % and 82 %) compared to LPS-stimulated control cells, along with increased release (134 % and 110 %) against COX-2 protein expressions.

Original language	English
Pages (from-to)	115-119
Number of pages	5
Journal	Phytochemistry Letters
Volume	61
DOIs	https://doi.org/10.1016/j.phytol.2024.03.015
Publication status	Published - Jun 2024

Keywords

Capnella imbricata
COX-2
INOS
Steroid

ASJC Scopus subject areas

Biotechnology
Biochemistry
Agronomy and Crop Science
Plant Science

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10.1016/j.phytol.2024.03.015

Cite this

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title = "Capnesterones A and B, new steroids isolated from the soft coral Capnella imbricata",

abstract = "Two new non-withanolidal steroids with a cross-conjugated dienone structural unit in ring A, capnesterones A (1) and B (2), were isolated from the soft coral Capnella imbricata in the southeast waters of Taiwan. The compounds' structures were elucidated through a comprehensive analysis of spectroscopic data, including IR, ESIMS, 1H NMR, and 13C NMR, and through comparison with previous literature. At a concentration of 10 μM, steroids 1 and 2 exhibited reductions in iNOS levels (60 % and 82 %) compared to LPS-stimulated control cells, along with increased release (134 % and 110 %) against COX-2 protein expressions.",

keywords = "Capnella imbricata, COX-2, INOS, Steroid",

author = "Cheng, {Ting Yu} and Yang, {Chia Jung} and Chen, {Po Jen} and Chen, {Yu Li} and Peng, {Bo Rong} and Kung, {Te An} and Wen, {Zhi Hong} and Lai, {Kuei Hung} and Chung, {Hsu Ming}",

note = "Publisher Copyright: {\textcopyright} 2024 Phytochemical Society of Europe",

year = "2024",

month = jun,

doi = "10.1016/j.phytol.2024.03.015",

language = "English",

volume = "61",

pages = "115--119",

journal = "Phytochemistry Letters",

issn = "1874-3900",

publisher = "Elsevier Ltd",

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TY - JOUR

T1 - Capnesterones A and B, new steroids isolated from the soft coral Capnella imbricata

AU - Cheng, Ting Yu

AU - Yang, Chia Jung

AU - Chen, Po Jen

AU - Chen, Yu Li

AU - Peng, Bo Rong

AU - Kung, Te An

AU - Wen, Zhi Hong

AU - Lai, Kuei Hung

AU - Chung, Hsu Ming

PY - 2024/6

Y1 - 2024/6

N2 - Two new non-withanolidal steroids with a cross-conjugated dienone structural unit in ring A, capnesterones A (1) and B (2), were isolated from the soft coral Capnella imbricata in the southeast waters of Taiwan. The compounds' structures were elucidated through a comprehensive analysis of spectroscopic data, including IR, ESIMS, 1H NMR, and 13C NMR, and through comparison with previous literature. At a concentration of 10 μM, steroids 1 and 2 exhibited reductions in iNOS levels (60 % and 82 %) compared to LPS-stimulated control cells, along with increased release (134 % and 110 %) against COX-2 protein expressions.

AB - Two new non-withanolidal steroids with a cross-conjugated dienone structural unit in ring A, capnesterones A (1) and B (2), were isolated from the soft coral Capnella imbricata in the southeast waters of Taiwan. The compounds' structures were elucidated through a comprehensive analysis of spectroscopic data, including IR, ESIMS, 1H NMR, and 13C NMR, and through comparison with previous literature. At a concentration of 10 μM, steroids 1 and 2 exhibited reductions in iNOS levels (60 % and 82 %) compared to LPS-stimulated control cells, along with increased release (134 % and 110 %) against COX-2 protein expressions.

KW - Capnella imbricata

KW - COX-2

KW - INOS

KW - Steroid

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DO - 10.1016/j.phytol.2024.03.015

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SN - 1874-3900

VL - 61

SP - 115

EP - 119

JO - Phytochemistry Letters

JF - Phytochemistry Letters

ER -

Capnesterones A and B, new steroids isolated from the soft coral Capnella imbricata

Abstract

Keywords

ASJC Scopus subject areas

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