Candidate single nucleotide polymorphisms associated with arsenic-induced Bowen's disease in Taiwan - A pilot study

Y. H. Wang; L. I. Hsu; C. J. Chen

doi:10.1201/b16767-190

Candidate single nucleotide polymorphisms associated with arsenic-induced Bowen's disease in Taiwan - A pilot study

Y. H. Wang
, L. I. Hsu
, C. J. Chen

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Arsenic-induced skin cancer may be considered a long-term biomarker of cumulative arsenic exposure. Therefore, we conducted a genome-wide screening to discover novel genes associated with chronic arsenic-induced skin cancers in Taiwan. We included 83 patients with skin cancer and 83 age-, gender - and arsenic exposure level-matched subjects were selected as controls. Then, we conducted a case-control study consisting of 144 skin cancer patients and 631 cancer-free controls for replicating the candidate single nucleotide polymorphisms (SNPs) identified from the genome-wide screening. In a genome-wide screening, we selected four top genes including SYN3(synapsin III), LOXL1(Lysyl Oxidase- Like1), AUH (Au-Specific RNA-binding Protein) and SEC24D (an essential coat protein II) for genotyping. Two SNPs (SYN3 rs137537 G/T and SEC24D rs13127508 G/A) were significantly associated with the risk of skin cancer. In this pilot study, we identify two novel genes including SYN3 and SEC24D which were significantly associated with arsenic-associated skin cancers in Taiwan.

Original language	English
Title of host publication	One Century of the Discovery of Arsenicosis in Latin America (1914-2014)
Subtitle of host publication	As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment
Publisher	CRC Press/Balkema
Pages	509-510
Number of pages	2
ISBN (Print)	9781138001411
DOIs	https://doi.org/10.1201/b16767-190
Publication status	Published - 2014
Event	5th International Congress on Arsenic in the Environment, As 2014 - Buenos Aires, Argentina Duration: May 11 2014 → May 16 2014

Publication series

Name	One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment

Other

Other	5th International Congress on Arsenic in the Environment, As 2014
Country/Territory	Argentina
City	Buenos Aires
Period	5/11/14 → 5/16/14

ASJC Scopus subject areas

Chemical Health and Safety

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1201/b16767-190

Cite this

Wang, Y. H., Hsu, L. I., & Chen, C. J. (2014). Candidate single nucleotide polymorphisms associated with arsenic-induced Bowen's disease in Taiwan - A pilot study. In One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment (pp. 509-510). (One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment). CRC Press/Balkema. https://doi.org/10.1201/b16767-190

Candidate single nucleotide polymorphisms associated with arsenic-induced Bowen's disease in Taiwan - A pilot study. / Wang, Y. H.; Hsu, L. I.; Chen, C. J.
One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment. CRC Press/Balkema, 2014. p. 509-510 (One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Wang, YH, Hsu, LI & Chen, CJ 2014, Candidate single nucleotide polymorphisms associated with arsenic-induced Bowen's disease in Taiwan - A pilot study. in One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment. One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment, CRC Press/Balkema, pp. 509-510, 5th International Congress on Arsenic in the Environment, As 2014, Buenos Aires, Argentina, 5/11/14. https://doi.org/10.1201/b16767-190

Wang YH, Hsu LI, Chen CJ. Candidate single nucleotide polymorphisms associated with arsenic-induced Bowen's disease in Taiwan - A pilot study. In One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment. CRC Press/Balkema. 2014. p. 509-510. (One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment). doi: 10.1201/b16767-190

Wang, Y. H. ; Hsu, L. I. ; Chen, C. J. / Candidate single nucleotide polymorphisms associated with arsenic-induced Bowen's disease in Taiwan - A pilot study. One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment. CRC Press/Balkema, 2014. pp. 509-510 (One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment).

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abstract = "Arsenic-induced skin cancer may be considered a long-term biomarker of cumulative arsenic exposure. Therefore, we conducted a genome-wide screening to discover novel genes associated with chronic arsenic-induced skin cancers in Taiwan. We included 83 patients with skin cancer and 83 age-, gender - and arsenic exposure level-matched subjects were selected as controls. Then, we conducted a case-control study consisting of 144 skin cancer patients and 631 cancer-free controls for replicating the candidate single nucleotide polymorphisms (SNPs) identified from the genome-wide screening. In a genome-wide screening, we selected four top genes including SYN3(synapsin III), LOXL1(Lysyl Oxidase- Like1), AUH (Au-Specific RNA-binding Protein) and SEC24D (an essential coat protein II) for genotyping. Two SNPs (SYN3 rs137537 G/T and SEC24D rs13127508 G/A) were significantly associated with the risk of skin cancer. In this pilot study, we identify two novel genes including SYN3 and SEC24D which were significantly associated with arsenic-associated skin cancers in Taiwan.",

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N2 - Arsenic-induced skin cancer may be considered a long-term biomarker of cumulative arsenic exposure. Therefore, we conducted a genome-wide screening to discover novel genes associated with chronic arsenic-induced skin cancers in Taiwan. We included 83 patients with skin cancer and 83 age-, gender - and arsenic exposure level-matched subjects were selected as controls. Then, we conducted a case-control study consisting of 144 skin cancer patients and 631 cancer-free controls for replicating the candidate single nucleotide polymorphisms (SNPs) identified from the genome-wide screening. In a genome-wide screening, we selected four top genes including SYN3(synapsin III), LOXL1(Lysyl Oxidase- Like1), AUH (Au-Specific RNA-binding Protein) and SEC24D (an essential coat protein II) for genotyping. Two SNPs (SYN3 rs137537 G/T and SEC24D rs13127508 G/A) were significantly associated with the risk of skin cancer. In this pilot study, we identify two novel genes including SYN3 and SEC24D which were significantly associated with arsenic-associated skin cancers in Taiwan.

AB - Arsenic-induced skin cancer may be considered a long-term biomarker of cumulative arsenic exposure. Therefore, we conducted a genome-wide screening to discover novel genes associated with chronic arsenic-induced skin cancers in Taiwan. We included 83 patients with skin cancer and 83 age-, gender - and arsenic exposure level-matched subjects were selected as controls. Then, we conducted a case-control study consisting of 144 skin cancer patients and 631 cancer-free controls for replicating the candidate single nucleotide polymorphisms (SNPs) identified from the genome-wide screening. In a genome-wide screening, we selected four top genes including SYN3(synapsin III), LOXL1(Lysyl Oxidase- Like1), AUH (Au-Specific RNA-binding Protein) and SEC24D (an essential coat protein II) for genotyping. Two SNPs (SYN3 rs137537 G/T and SEC24D rs13127508 G/A) were significantly associated with the risk of skin cancer. In this pilot study, we identify two novel genes including SYN3 and SEC24D which were significantly associated with arsenic-associated skin cancers in Taiwan.

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Candidate single nucleotide polymorphisms associated with arsenic-induced Bowen's disease in Taiwan - A pilot study

Abstract

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