Cancer-targeted fucoidan‑iron oxide nanoparticles for synergistic chemotherapy/chemodynamic theranostics through amplification of P-selectin and oxidative stress

Thi Luu Ho, Chinmaya Mutalik, Lekshmi Rethi, Huynh Ngoc Truc Nguyen, Pei Ru Jheng, Chin Chean Wong, Tzu Sen Yang, Thi Thuy Nguyen, Bradley W. Mansel, Chen An Wang, Er Yuan Chuang

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

A combination of chemotherapy and chemodynamic therapy (CDT) is being developed to improve the theranostic efficacy and biological safety of current therapies. However, most CDT agents are restricted due to complex issues such as multiple components, low colloidal stability, carrier-associated toxicity, insufficient reactive oxygen species generation, and poor targeting efficacy. To overcome these problems, a novel nanoplatform composed of fucoidan (Fu) and iron oxide (IO) nanoparticles (NPs) was developed to achieve chemotherapy combined with CDT synergistic treatment with a facile self-assembling manner, and the NPs were made up of Fu and IO, in which the Fu was not only used as a potential chemotherapeutic but was also designed to stabilize the IO and target P-selectin-overexpressing lung cancer cells, thereby producing oxidative stress and thus synergizing the CDT efficacy. The Fu-IO NPs exhibited a suitable diameter below 300 nm, which favored their cellular uptake by cancer cells. Microscopic and MRI data confirmed the lung cancer cellular uptake of the NPs due to active Fu targeting. Moreover, Fu-IO NPs induced efficient apoptosis of lung cancer cells, and thus offer significant anti-cancer functions by potential chemotherapeutic-CDT.

Original languageEnglish
Article number123821
JournalInternational Journal of Biological Macromolecules
Volume235
DOIs
Publication statusPublished - Apr 2023

Keywords

  • Amplification of P-selectin and oxidative stress
  • Cancer-targeted fucoidan‑iron oxide nanoparticles
  • Synergistic chemotherapy/chemodynamic theranostics

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Molecular Biology

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