Abstract
NPM1 gene mutation evaluated on a population basis is a valuable and realistic tool to reflect the pathophysiological relevance of cancer. In a comparison of the NPM1 cDNA of human bladder cancer with its consensus sequence, we have found that a higher NPM1 sequence identity in a population is consistent with poor tumor differentiation, advanced tumor stage, and likelihood of recurrence. These data imply that "probability" of NPM1 mutation is an indicator of status of malignancy.
| Original language | English |
|---|---|
| Pages (from-to) | 746-750 |
| Number of pages | 5 |
| Journal | Genomics |
| Volume | 90 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Dec 2007 |
| Externally published | Yes |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Gene identity
- Genetic variations
- Nucleophosmin
- Population genetics
- Probability of mutation
ASJC Scopus subject areas
- Genetics
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