Can mixed pure hepatocellular carcinoma and germinoma arise together in the brain?

Lu Jen Chen, I. Chun Lai, Tai Tong Wong, Shih Chieh Lin, Donald Ming Tak Ho, Kai Ping Chang, Wan Yuo Guo, Sang-Hue Yen, Ming Teh Chen, Yi Wei Chen

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Intracranial germ-cell tumors (GCTs) represent 10-15% of all pediatric brain tumors in East Asia. There is a wide histopathological spectrum of intracranial GCTs. Germinomas and nongerminomatous GCTs are the two major classifications. It is difficult to distinguish different subtypes of intracranial GCTs based solely on imaging studies, however, some tumor markers, such as α-fetoprotein or β-human chorionic gonadotropin, are helpful for diagnosis. In this study we present the case of a 13-year-old girl with an intracranial mixed GCT containing a hepatocellular carcinoma and germinoma without a primary liver tumor. Based on this unique pathological diagnosis, a series of treatments were applied, including surgery for gross tumor removal, adjuvant radiotherapy, and chemotherapy. Long-term follow up indicates fair disease control.

Original languageEnglish
Pages (from-to)562-566
Number of pages5
JournalJournal of the Chinese Medical Association
Issue number9
Publication statusPublished - Sept 1 2015
Externally publishedYes


  • Germ-cell tumor
  • Germinoma
  • Hepatocellular carcinoma
  • Pediatric brain tumor
  • Radiotherapy

ASJC Scopus subject areas

  • General Medicine


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