Calcium release from different toothpastes after the incorporation of tricalcium phosphate and amorphous calcium phosphate

Ping Jen Hou, Chang Yu Lee, Keng Liang Ou, Wen Chien Lan, Yen Chun Chuo, Hung Yang Lin, Hsiao Wei Chao, Bai Hung Huang, Takashi Saito, Hsin Yu Tsai, Tzu Sen Yang, Christopher J. Walinski, Muhammad Ruslin

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


This study aimed to investigate the free calcium released from different brands of toothpaste after incorporation with a beta‐tricalcium phosphate (β‐TCP)/amorphous calcium phosphate (ACP) mixed powder and with β‐TCP powder alone. Four brands of toothpaste were used for the experiment: Nano‐Bio Activation Toothpaste, Colgate Total Advanced Whitening Toothpaste, BORONIA Herbal Whitening, and BioMin F. The investigated β‐TCP and ACP powders were prepared by a two‐step sintering method using raw coral material. Analytical results found that the mean calcium concentration of the β‐TCP/ACP (2:1) powder in deionized water was 3.4% when the pH was between 5 and 9. Moreover, statistical results revealed that the toothpaste containing β‐TCP powder had significantly higher calcium concentrations than the normal toothpaste. The toothpaste containing mixed β‐TCP/ACP powder had a higher calcium concentration than the toothpaste containing only β‐TCP powder. Twice as much free calcium could be released from β‐TCP/ACP toothpaste than from β‐TCP‐only toothpaste. Thus, toothpaste containing β‐TCP/ACP mixed powder offers greater benefits to facilitate the remineralization of enamel than toothpaste containing only β‐TCP.

Original languageEnglish
Article number1848
Pages (from-to)1-12
Number of pages12
JournalApplied Sciences (Switzerland)
Issue number4
Publication statusPublished - Feb 2 2021


  • Amorphous calcium phosphate
  • Remineralization
  • Two–step sintering
  • β‐tricalcium phosphate

ASJC Scopus subject areas

  • General Materials Science
  • Instrumentation
  • General Engineering
  • Process Chemistry and Technology
  • Computer Science Applications
  • Fluid Flow and Transfer Processes


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