Calcium Phosphate Nanoclusters for the Repair of Tooth Enamel Erosion

Chia Hsien Wang, Chinmaya Mutalik, Sibidou Yougbaré, Nai Chia Teng, Tsung Rong Kuo

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


The artificial repair of tooth enamel is still an urgent requirement because it has a complicated and well-arranged structure. Herein, calcium phosphate nanoclusters (CaP NCs) were synthesized, via a facile approach, for application in the repair of tooth enamel erosion. Structural and optical characterizations validated the successful preparation of spherical CaP NCs, with an average size of 2.1 ± 0.11 nm. By evaporating the ethanol and triethylamine (TEA) solvents, pure CaP was produced, which was further used to repair the tooth enamel. Simulated caries lesions were achieved via phosphoric acid etching to cause damage to enamel rods. After repair, the damaged enamel rods were directly covered with CaP. According to microhardness testing, after repair with CaP NCs, the hardness value of the tooth enamel with acid etching increased to a similar level to that of normal tooth enamel. The results of the microhardness test indicated that CaP NCs revealed great potential for repairing tooth enamel erosion. Our work demonstrates a promising potential for treating the early stage of tooth erosion with CaP NCs. Based on these findings, we believe that stable CaP NCs can be employed as a precursor for the tunable, effective repair of tooth enamel in the near future.

Original languageEnglish
Article number1997
Issue number12
Publication statusPublished - Jun 1 2022


  • calcium phosphates
  • enamel rod
  • microhardness test
  • nanocluster
  • repair
  • tooth enamel

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Materials Science(all)


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