By inhibiting snail signaling and miR-23a-3p, osthole suppresses the EMT-mediated metastatic ability in prostate cancer

Yu-Ching Wen; Wei Jiunn Lee; Peng Tan; Shun Fa Yang; Michael Hsiao; Liang Ming Lee; Ming Hsien Chien

doi:10.18632/oncotarget.4229

By inhibiting snail signaling and miR-23a-3p, osthole suppresses the EMT-mediated metastatic ability in prostate cancer

Yu-Ching Wen, Wei Jiunn Lee, Peng Tan, Shun Fa Yang, Michael Hsiao, Liang Ming Lee, Ming Hsien Chien

Research output: Contribution to journal › Article › peer-review

74 Citations (Scopus)

Abstract

Here we showed that Osthole, 7-methoxy-8-(3-methyl-2-butenyl) coumarin, a bioactive coumarin derivative extracted from medicinal plants, inhibited migration, invasion, epithelial to mesenchymal transition (EMT) in androgen-independent prostate cancer (AIPC) cells in vitro and metastasis of AIPC in vivo. In patients, high Snail levels were correlated with a higher histological Gleason sum and poor survival rates. Osthole inhibited the TGF-β/Akt/MAPK pathways, reduced Snail-DNAbinding activity and induced E-cadherin. We found that osthole decreased miR-23a-3p. Ectopic miR-23a-3p suppressed E-cadherin 3' untranslated region reporter activity and E-cadherin expression, and relieved the motility suppression caused by osthole treatment.

Original language	English
Pages (from-to)	21120-21136
Number of pages	17
Journal	Oncotarget
Volume	6
Issue number	25
DOIs	https://doi.org/10.18632/oncotarget.4229
Publication status	Published - 2015

Keywords

EMT
MiR-23a-3p
Osthole
Prostate cancer
Snail

ASJC Scopus subject areas

Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.18632/oncotarget.4229

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title = "By inhibiting snail signaling and miR-23a-3p, osthole suppresses the EMT-mediated metastatic ability in prostate cancer",

abstract = "Here we showed that Osthole, 7-methoxy-8-(3-methyl-2-butenyl) coumarin, a bioactive coumarin derivative extracted from medicinal plants, inhibited migration, invasion, epithelial to mesenchymal transition (EMT) in androgen-independent prostate cancer (AIPC) cells in vitro and metastasis of AIPC in vivo. In patients, high Snail levels were correlated with a higher histological Gleason sum and poor survival rates. Osthole inhibited the TGF-β/Akt/MAPK pathways, reduced Snail-DNAbinding activity and induced E-cadherin. We found that osthole decreased miR-23a-3p. Ectopic miR-23a-3p suppressed E-cadherin 3' untranslated region reporter activity and E-cadherin expression, and relieved the motility suppression caused by osthole treatment.",

keywords = "EMT, MiR-23a-3p, Osthole, Prostate cancer, Snail",

author = "Yu-Ching Wen and Lee, {Wei Jiunn} and Peng Tan and Yang, {Shun Fa} and Michael Hsiao and Lee, {Liang Ming} and Chien, {Ming Hsien}",

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AU - Wen, Yu-Ching

AU - Lee, Wei Jiunn

AU - Tan, Peng

AU - Yang, Shun Fa

AU - Hsiao, Michael

AU - Lee, Liang Ming

AU - Chien, Ming Hsien

PY - 2015

Y1 - 2015

N2 - Here we showed that Osthole, 7-methoxy-8-(3-methyl-2-butenyl) coumarin, a bioactive coumarin derivative extracted from medicinal plants, inhibited migration, invasion, epithelial to mesenchymal transition (EMT) in androgen-independent prostate cancer (AIPC) cells in vitro and metastasis of AIPC in vivo. In patients, high Snail levels were correlated with a higher histological Gleason sum and poor survival rates. Osthole inhibited the TGF-β/Akt/MAPK pathways, reduced Snail-DNAbinding activity and induced E-cadherin. We found that osthole decreased miR-23a-3p. Ectopic miR-23a-3p suppressed E-cadherin 3' untranslated region reporter activity and E-cadherin expression, and relieved the motility suppression caused by osthole treatment.

AB - Here we showed that Osthole, 7-methoxy-8-(3-methyl-2-butenyl) coumarin, a bioactive coumarin derivative extracted from medicinal plants, inhibited migration, invasion, epithelial to mesenchymal transition (EMT) in androgen-independent prostate cancer (AIPC) cells in vitro and metastasis of AIPC in vivo. In patients, high Snail levels were correlated with a higher histological Gleason sum and poor survival rates. Osthole inhibited the TGF-β/Akt/MAPK pathways, reduced Snail-DNAbinding activity and induced E-cadherin. We found that osthole decreased miR-23a-3p. Ectopic miR-23a-3p suppressed E-cadherin 3' untranslated region reporter activity and E-cadherin expression, and relieved the motility suppression caused by osthole treatment.

KW - EMT

KW - MiR-23a-3p

KW - Osthole

KW - Prostate cancer

KW - Snail

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ER -

By inhibiting snail signaling and miR-23a-3p, osthole suppresses the EMT-mediated metastatic ability in prostate cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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