Boron-rich, cytocompatible block copolymer nanoparticles by polymerization-induced self-assembly

Lin Chiang Sherlock Huang; Dao Le; I. Lun Hsiao; Susanne Fritsch-Decker; Christian Hald; Su Ching Huang; Jen Kun Chen; Jih Ru Hwu; Carsten Weiss; Min Hua Hsu; Guillaume Delaittre

doi:10.1039/d0py00710b

Boron-rich, cytocompatible block copolymer nanoparticles by polymerization-induced self-assembly

Lin Chiang Sherlock Huang
, Dao Le
, I. Lun Hsiao
, Susanne Fritsch-Decker
, Christian Hald
, Su Ching Huang
, Jen Kun Chen
, Jih Ru Hwu
, Carsten Weiss
, Min Hua Hsu
, Guillaume Delaittre

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Core-shell nanoparticles (NPs) with a boron-rich core were synthesized by RAFT-mediated polymerization-induced self-assembly using a new methacrylic boronate ester monomer. Under specific conditions, sub-100 nm spherical NPs could be obtained at high conversions by either emulsion or dispersion RAFT polymerization using poly(oligo(ethylene glycol) methacrylate) (POEGMA) dithiobenozate-based chain transfer agents. Phenylboronic acid surface-functionalized NPs were obtained using a telechelic POEGMA. Primary data on biocompatibility is provided and suggests suitability as boron delivery agent for boron neutron capture therapy. This journal is

Original language	English
Pages (from-to)	50-56
Number of pages	7
Journal	Polymer Chemistry
Volume	12
Issue number	1
DOIs	https://doi.org/10.1039/d0py00710b
Publication status	Published - Jan 7 2021

ASJC Scopus subject areas

Bioengineering
Biochemistry
Polymers and Plastics
Organic Chemistry

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10.1039/d0py00710b

Cite this

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abstract = "Core-shell nanoparticles (NPs) with a boron-rich core were synthesized by RAFT-mediated polymerization-induced self-assembly using a new methacrylic boronate ester monomer. Under specific conditions, sub-100 nm spherical NPs could be obtained at high conversions by either emulsion or dispersion RAFT polymerization using poly(oligo(ethylene glycol) methacrylate) (POEGMA) dithiobenozate-based chain transfer agents. Phenylboronic acid surface-functionalized NPs were obtained using a telechelic POEGMA. Primary data on biocompatibility is provided and suggests suitability as boron delivery agent for boron neutron capture therapy. This journal is ",

author = "Huang, \{Lin Chiang Sherlock\} and Dao Le and Hsiao, \{I. Lun\} and Susanne Fritsch-Decker and Christian Hald and Huang, \{Su Ching\} and Chen, \{Jen Kun\} and Hwu, \{Jih Ru\} and Carsten Weiss and Hsu, \{Min Hua\} and Guillaume Delaittre",

note = "Funding Information: L-C. S. H. thanks the Ministry of Science and Technology of the Republic of China (MOST) and the German Academic Exchange Service (DAAD) for his DAAD-MOST Sandwich fellowship. D. L. thanks the Alexander von Humboldt Foundation for his postdoctoral fellowship. J. R. H. and M.-H. H. thank MOST (Grant No. 109-2634-F-007-023) as well. The Macroarc group (ITCP, KIT) and the Levkin lab (IBCS-FMS, KIT) are gratefully acknowledged for access to SEC and DLS instruments, respectively. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2021",

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doi = "10.1039/d0py00710b",

language = "English",

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AU - Huang, Lin Chiang Sherlock

AU - Le, Dao

AU - Hsiao, I. Lun

AU - Fritsch-Decker, Susanne

AU - Hald, Christian

AU - Huang, Su Ching

AU - Chen, Jen Kun

AU - Hwu, Jih Ru

AU - Weiss, Carsten

AU - Hsu, Min Hua

AU - Delaittre, Guillaume

N1 - Funding Information: L-C. S. H. thanks the Ministry of Science and Technology of the Republic of China (MOST) and the German Academic Exchange Service (DAAD) for his DAAD-MOST Sandwich fellowship. D. L. thanks the Alexander von Humboldt Foundation for his postdoctoral fellowship. J. R. H. and M.-H. H. thank MOST (Grant No. 109-2634-F-007-023) as well. The Macroarc group (ITCP, KIT) and the Levkin lab (IBCS-FMS, KIT) are gratefully acknowledged for access to SEC and DLS instruments, respectively. Publisher Copyright: © The Royal Society of Chemistry. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/1/7

Y1 - 2021/1/7

N2 - Core-shell nanoparticles (NPs) with a boron-rich core were synthesized by RAFT-mediated polymerization-induced self-assembly using a new methacrylic boronate ester monomer. Under specific conditions, sub-100 nm spherical NPs could be obtained at high conversions by either emulsion or dispersion RAFT polymerization using poly(oligo(ethylene glycol) methacrylate) (POEGMA) dithiobenozate-based chain transfer agents. Phenylboronic acid surface-functionalized NPs were obtained using a telechelic POEGMA. Primary data on biocompatibility is provided and suggests suitability as boron delivery agent for boron neutron capture therapy. This journal is

AB - Core-shell nanoparticles (NPs) with a boron-rich core were synthesized by RAFT-mediated polymerization-induced self-assembly using a new methacrylic boronate ester monomer. Under specific conditions, sub-100 nm spherical NPs could be obtained at high conversions by either emulsion or dispersion RAFT polymerization using poly(oligo(ethylene glycol) methacrylate) (POEGMA) dithiobenozate-based chain transfer agents. Phenylboronic acid surface-functionalized NPs were obtained using a telechelic POEGMA. Primary data on biocompatibility is provided and suggests suitability as boron delivery agent for boron neutron capture therapy. This journal is

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Boron-rich, cytocompatible block copolymer nanoparticles by polymerization-induced self-assembly

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