Abstract
Background: The aim of this study is to investigate the prevalence of osteoporosis and risk factors for decreased bone mineral density in adults with hemophilia in Taiwan.
Methods: We recruited 14 adults with hemophilia and retrospectively analyzed their clinical records in 2007. Clinical features of hemophilia demonstrated were analyzed.
Results: Three patients were excluded due to amputation, long-term steroid use, and incorporation. Among the 11 patients, seven (63.6%) had hemophilia A and four (36.4%) had hemophilia B. Mean age was 29.6 ± 9.8 years-old, ranging from 18 to 45 years-old. Mean age at diagnosis was 81.2 ± 87.5 months-old, ranging from 10 to 252 months-old. Osteoporosis was only found in one patient (9.1%). Osteopenia was only found in two patients (18.2%). Eight patients (72.7%) were found with normal BMD. BL less than 170 cm among hemophiliacs is significantly associated with decreased BMD (P = 0.045). BW less than 60 kg and BSA less than 1.73 m2 among hemophiliacs are marginally significantly associated with decreased BMD, respectively P = 0.068 and P = 0.068. More than four target joints affected in lower limbs among hemophiliacs is marginally significantly associated with decreased BMD (P = 0.084). However, age, age
at diagnosis, type of hemophilia, BMI, HCV infection, HBV infection, family history, the number of the target joints of upper limbs affected are not associated with BMD.
Conclusions: Osteoporosis and osteopenia in adults with hemophilia in Taiwan are not common compared with those of reports in other nations. Hemophiliacs with BL less than 170 cm, BW less than 60 kg, or BSA less than 1.73 m2
, or more than four target joints in lower limbs affected might have more possibility of decreased BMD and could benefit from a BMD examination.
Methods: We recruited 14 adults with hemophilia and retrospectively analyzed their clinical records in 2007. Clinical features of hemophilia demonstrated were analyzed.
Results: Three patients were excluded due to amputation, long-term steroid use, and incorporation. Among the 11 patients, seven (63.6%) had hemophilia A and four (36.4%) had hemophilia B. Mean age was 29.6 ± 9.8 years-old, ranging from 18 to 45 years-old. Mean age at diagnosis was 81.2 ± 87.5 months-old, ranging from 10 to 252 months-old. Osteoporosis was only found in one patient (9.1%). Osteopenia was only found in two patients (18.2%). Eight patients (72.7%) were found with normal BMD. BL less than 170 cm among hemophiliacs is significantly associated with decreased BMD (P = 0.045). BW less than 60 kg and BSA less than 1.73 m2 among hemophiliacs are marginally significantly associated with decreased BMD, respectively P = 0.068 and P = 0.068. More than four target joints affected in lower limbs among hemophiliacs is marginally significantly associated with decreased BMD (P = 0.084). However, age, age
at diagnosis, type of hemophilia, BMI, HCV infection, HBV infection, family history, the number of the target joints of upper limbs affected are not associated with BMD.
Conclusions: Osteoporosis and osteopenia in adults with hemophilia in Taiwan are not common compared with those of reports in other nations. Hemophiliacs with BL less than 170 cm, BW less than 60 kg, or BSA less than 1.73 m2
, or more than four target joints in lower limbs affected might have more possibility of decreased BMD and could benefit from a BMD examination.
| Original language | English |
|---|---|
| Article number | 06P16 |
| Pages (from-to) | 22 |
| Number of pages | 1 |
| Journal | Haemophilia |
| Volume | 16 |
| Issue number | Supplement 4 |
| DOIs | |
| Publication status | Published - Jul 1 2010 |