TY - JOUR
T1 - Body composition patterns among normal glycemic, pre-diabetic, diabetic health Chinese adults in community
T2 - NAHSIT 2013–2016
AU - Lin, Sheng Feng
AU - Fan, Yen Chun
AU - Chou, Chia Chi
AU - Pan, Wen Harn
AU - Bai, Chyi Huey
N1 - Funding Information:
This work was funded by the Health Promotion Administration, Ministry of Health and Welfare (MOHW108-HPA-H-114-134703, MOHW109-HPA-H-114-144702), as well as funded by Ministry of Science and Technology, Taiwan in the form of a grant awarded to CHB (MOST 107-2314-B-038-072-MY3). The Health Promotion Administration, Ministry of Health and Welfare, Taiwan is the governmental entity. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Publisher Copyright:
© 2020 Lin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2020/11
Y1 - 2020/11
N2 - Background Central obesity is known to be associated with diabetes. Increasing lower extremity circumference was hypothesized in association with lower risk of diabetes. Objective This study determined which anthropometric patterns correlates the best with pre-diabetic and diabetic status among healthy adults. Design Cross-sectional study with nationwide population sampling of participants was designed. Participants In total, 1,358 ethnic Chinese adult participants were recruited from the Nutrition and Health Survey in Taiwan 2013–2016; the whole-body composition was measured through dual-energy X-ray absorptiometry. Main outcome measures Fat and lean mass in whole and specific parts of body among heathy Asian adults with normal glycemic, pre-diabetic, and diabetic states were measured, separately. Statistical analyses performed The generalized linear model was used to investigate the association between body composition (lean and fat mass) and hyperglycemic status. The reduced rank regression (RRR) was used to confirm the correlation between glycemic status and predicting factors (body composition parameters). Results Trunk fat positively correlated with the fasting glucose level (r = 0.327, P < 0.001) and HbA1c (r = 0.329, P < 0.001), whereas limb fat negatively correlated with the fasting glucose level (r = −0.325, P < 0.001) and HbA1c (ρ = −0.342, P < 0.001), respectively. In RRR analyses, fasting glucose and HbA1c exhibited a high positive association on fat amount per lean mass of the trunk (factor loading = 0.5319 and 0.5599, respectively) and of android area (0.6422 and 0.6104) and a high negative association fat amount per lean mass of the legs (−0.3863 and −0.3083) and gynoid area (−0.3414 and −0.3725). Conclusions For healthy community participants, increasing trunk fat had a greater risk of hyperglycemic status. Increasing lower extremity mass may confer lower risk of diabetes.
AB - Background Central obesity is known to be associated with diabetes. Increasing lower extremity circumference was hypothesized in association with lower risk of diabetes. Objective This study determined which anthropometric patterns correlates the best with pre-diabetic and diabetic status among healthy adults. Design Cross-sectional study with nationwide population sampling of participants was designed. Participants In total, 1,358 ethnic Chinese adult participants were recruited from the Nutrition and Health Survey in Taiwan 2013–2016; the whole-body composition was measured through dual-energy X-ray absorptiometry. Main outcome measures Fat and lean mass in whole and specific parts of body among heathy Asian adults with normal glycemic, pre-diabetic, and diabetic states were measured, separately. Statistical analyses performed The generalized linear model was used to investigate the association between body composition (lean and fat mass) and hyperglycemic status. The reduced rank regression (RRR) was used to confirm the correlation between glycemic status and predicting factors (body composition parameters). Results Trunk fat positively correlated with the fasting glucose level (r = 0.327, P < 0.001) and HbA1c (r = 0.329, P < 0.001), whereas limb fat negatively correlated with the fasting glucose level (r = −0.325, P < 0.001) and HbA1c (ρ = −0.342, P < 0.001), respectively. In RRR analyses, fasting glucose and HbA1c exhibited a high positive association on fat amount per lean mass of the trunk (factor loading = 0.5319 and 0.5599, respectively) and of android area (0.6422 and 0.6104) and a high negative association fat amount per lean mass of the legs (−0.3863 and −0.3083) and gynoid area (−0.3414 and −0.3725). Conclusions For healthy community participants, increasing trunk fat had a greater risk of hyperglycemic status. Increasing lower extremity mass may confer lower risk of diabetes.
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U2 - 10.1371/journal.pone.0241121
DO - 10.1371/journal.pone.0241121
M3 - Review article
C2 - 33147251
AN - SCOPUS:85095678182
SN - 1932-6203
VL - 15
JO - PLoS ONE
JF - PLoS ONE
IS - 11 November
M1 - e0241121
ER -
