6 Citations (Scopus)

Abstract

Systemic inflammation, neurovascular dysfunction, and coagulopathy often occur concurrently in neuropathologies. Neutrophils and platelets have crucial synergistic roles in thromboinflammation and are increasingly suspected as effector cells contributing to the pathogenesis of neuroinflammatory diseases. In this review, we summarize the roles of platelet–neutrophil interactions in triggering complex pathophysiological events affecting the brain that may lead to the disruption of brain barriers, infiltration of toxic factors into the parenchyma, and amplification of neuroinflammation through the formation of neutrophil extracellular traps (NETs). We highlight the clinical significance of thromboinflammation in neurological disorders and examine the contributions of damage-associated molecular patterns (DAMPs) derived from platelets and neutrophils. These DAMPs originate from both infectious and non-infectious risk factors and contribute to the activation of inflammasomes during brain disorders. Finally, we identify knowledge gaps in the molecular mechanisms underlying neurodegenerative disease pathogenesis and emphasize the potential of interventions targeting platelets and neutrophils to treat neuroinflammatory diseases.

Original languageEnglish
Pages (from-to)764-779
Number of pages16
JournalTrends in Neurosciences
Volume46
Issue number9
DOIs
Publication statusPublished - Sept 2023

Keywords

  • extracellular vesicles
  • neurodegeneration
  • neuroimmune
  • neuroinflammation
  • Thromboinflammation
  • viral infection

ASJC Scopus subject areas

  • General Neuroscience

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