Abstract
The effects of tetrahydro-9-aminoacridine (THA) on β-adrenoceptor activation-induced synaptic potentiation were studied in brain slices of the rat amygdala using intracellular recording techniques. To exclude the involvement of N-methyl-D-aspartate (NMDA) receptors, all the experiments were performed in the presence of NMDA receptor antagonist, D-APV (50 μM). Bath application of isoproterenol (Iso; 15 μM) results in a long-lasting enhancement of the amplitude of excitatory postsynaptic potentials (EPSPs) to 200 ± 6% of baseline. Forskolin, which directly activates adenyl cyclase, produces a similar effect suggesting that Iso may act through a cyclic AMP-dependent mechanism. Pretreatment of the slices with THA (300 μM) completely abolishes the Iso- and forskolin-induced synaptic potentiation. We hypothesize that the locus of THA/β-adrenoceptor interaction is presynaptic; the underlying mechanism is likely due to THA's depression of transmitter release via a presynaptic blockade of voltage-dependent Ca2+ channels.
Original language | English |
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Pages (from-to) | 87-90 |
Number of pages | 4 |
Journal | Neuroscience Letters |
Volume | 214 |
Issue number | 2-3 |
DOIs | |
Publication status | Published - Aug 23 1996 |
Externally published | Yes |
Keywords
- Amygdala
- Forskolin
- Isoproterenol
- Long-term potentiation
- Tetrahydro-9-aminoacridine
ASJC Scopus subject areas
- Neuroscience(all)