@article{fbd82b5bb03d4cb9bd6771d7cc2a51b6,
title = "Biosynthesis of Vitroprocines by α-Oxoamine Synthase and Oxidoreductase Identified from Vibrio sp. QWI-06",
abstract = "A specific α-oxoamine synthase (VsAOS-2) and an oxidoreductase (VsOR) identified from marine Vibrio sp. QWI-06 were involved in the decarboxylative condensation of l-tyrosine to lauroyl-CoA following the reduction of the ketone group to form vitroprocine-type compound 1. The intermediates and products were characterized through HR-MS and their MS/MS fragmentations. This study reveals the biosynthetic pathway of vitroprocines and provides a useful model for elucidating the reaction mechanism underlying the production of amino acid-polyketide derivatives in microorganisms.",
author = "Liaw, {Chih Chuang} and Lo, {Li Hua} and Cheng, {Tien Hsing} and Chan, {Yuen Ting} and Huang, {Yu Ru} and Wang, {Andrew H.J.} and Chang, {Hsin Yang}",
note = "Funding Information: We thank the National Research Program for Biopharmaceuticals, the National Center for High Performance Computing, National Applied Research Laboratories of Taiwan for providing computing resources. This research work was supported in part by Ministry of Science and Technology grants (MOST108-2320-B-110-006-MY3) to CCL and (MOST 109-2311-B-010-007-MY3) to HYC, respectively, a grant from the National Sun Yat-sen University-Kaohsiung Medical University Joint Research Project (NSYSU-KMU 109-I005), and the Taiwan Protein Project (Grant No. AS-KPQ-109-TPP2) to CCL and HYC. Publisher Copyright: {\textcopyright} 2022 American Chemical Society. All rights reserved.",
year = "2022",
month = may,
day = "6",
doi = "10.1021/acs.orglett.2c01178",
language = "English",
volume = "24",
pages = "3281--3285",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "17",
}
