Biosensor and Lab-on-a-chip Biomarker-identifying Technologies for Oral and Periodontal Diseases

Larissa Steigmann, Shogo Maekawa, Corneliu Sima, Suncica Travan, Chin Wei Wang, William V. Giannobile

Research output: Contribution to journalReview articlepeer-review

22 Citations (Scopus)


Periodontitis is a complex multifactorial disease that can lead to destruction of tooth supporting tissues and subsequent tooth loss. The most recent global burden of disease studies highlight that severe periodontitis is one of the most prevalent chronic inflammatory conditions affecting humans. Periodontitis risk is attributed to genetics, host-microbiome and environmental factors. Empirical diagnostic and prognostic systems have yet to be validated in the field of periodontics. Early diagnosis and intervention prevents periodontitis progression in most patients. Increased susceptibility and suboptimal control of modifiable risk factors can result in poor response to therapy, and relapse. The chronic immune-inflammatory response to microbial biofilms at the tooth or dental implant surface is associated with systemic conditions such as cardiovascular disease, diabetes or gastrointestinal diseases. Oral fluid-based biomarkers have demonstrated easy accessibility and potential as diagnostics for oral and systemic diseases, including the identification of SARS-CoV-2 in saliva. Advances in biotechnology have led to innovations in lab-on-a-chip and biosensors to interface with oral-based biomarker assessment. This review highlights new developments in oral biomarker discovery and their validation for clinical application to advance precision oral medicine through improved diagnosis, prognosis and patient stratification. Their potential to improve clinical outcomes of periodontitis and associated chronic conditions will benefit the dental and overall public health.

Original languageEnglish
Article number588480
JournalFrontiers in Pharmacology
Publication statusPublished - Nov 9 2020
Externally publishedYes


  • biomarkers
  • biotechnology
  • patient stratification
  • periodontal diseases/periodontitis
  • precision medicine
  • saliva

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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