Biomechanical behavior of a hydrogel-based TDR device

C. Y. Lin, S. Y. Chuang, Y. H. Tsuang, W. P. Chen

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Degenerative disc disease is one of the most common diseases resulting from inflammation and instability around the affected spinal disc. Total disc replacement (TDR) is one non-fusion technique emerging as potential solutions to this condition, which can be used to restore normal motion in the spine. Although the first generation TDR devices have reasonable clinical results, similar to fusion, but several concerns in the current technologies are the inability to provide adequate shock absorption capability and time-dependent biomechanical behaviors. In order to improve this problem, second generation TDR devices incorporate more properties of a natural disc. Therefore, the objective of this study is to develop a novel biomimetic TDR device, and to demonstrate scientifically whether its biomechanical behavior is similar to that of a natural disc. Three-dimensional finite element (FE) models of a lumbar spinal motion segment (L4-5) with implants including Charité, Maverick, and the hydrogel-based TDR devices were created. With these models, the three different TDR design concepts were compared with respect to their ability to mimic the behavior of a natural disc. The analysis results indicate that the hydrogel-based TDR device could maintain the ROM well compared to that of a natural disc. However, the model with the novel TDR device predicted a marked increase of facet joint forces due to the relatively low rotational stiffness, especially in lateral bending. Although many steps are still necessary before the hydrogel-based TDR device can be used in clinical surgery to relieve back and leg pain associated with DDD. The results provide further insight into the biomechanical behavior of this novel TDR device under comparable physiologic loading conditions, and indicate that it is a feasible and promising approach.

Original languageEnglish
Title of host publication1st Global Conference on Biomedical Engineering and 9th Asian-Pacific Conference on Medical and Biological Engineering
EditorsFong-Chin Su, Ming-Long Yeh, Shyh-Hau Wang
PublisherSpringer Verlag
Number of pages4
ISBN (Electronic)9783319122618
Publication statusPublished - 2015
Event1st Global Conference on Biomedical Engineering, GCBME 2014 and 9th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2014 - Tainan, Taiwan
Duration: Oct 9 2014Oct 12 2014

Publication series

NameIFMBE Proceedings
ISSN (Print)1680-0737
ISSN (Electronic)1433-9277


Other1st Global Conference on Biomedical Engineering, GCBME 2014 and 9th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2014


  • Degenerative disc disease
  • Finite element analysis
  • Total disc replacement

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering


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