Biological Transporters as Targets for New Drug Design

Hui Po Wang, Chun Li Wang

Research output: Contribution to journalReview articlepeer-review

10 Citations (Scopus)


The biological system, which forms the basis for drug-host, drug-food, and drug-drug interactions, is full of mechanisms designed to manipulate drug action. These mechanisms, namely absorption, distribution, metabolism, and excretion (ADME), thus become targets in pharmaceutical research for optimizing the pharmacodynamic/pharmacokinetic profiles of drugs. The body system is also full of resources, such as transporters, for designing new chemical entities as therapeutic agents. This review highlights current research in using biological transporters as a proactive approach in drug delivery to optimize efficacy in the early stages of drug development, and as a target for rational design of prodrugs as novel therapeutic agents. The structural design of prodrugs using delivery moieties such as D-phenylglycine for improving intestinal absorption of levodopa is presented as an example.

Original languageEnglish
Pages (from-to)31-38
Number of pages8
JournalJournal of Experimental and Clinical Medicine
Issue number1
Publication statusPublished - Dec 2009


  • ADME
  • PEPT1
  • delivery system
  • prodrug
  • transporter

ASJC Scopus subject areas

  • General Medicine


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