Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework

Edward J. Calabrese; Kenneth A. Bachmann; A. John Bailer; P. Michael Bolger; Jonathan Borak; Lu Cai; Nina Cedergreen; M. George Cherian; Juang-Ching Chiue; Thomas W. Clarkson; Ralph R. Cook; David M. Diamond; David J. Doolittle; Michael A. Dorato; Stephen O. Duke; Ludwig Feinendegen; Donald E. Gardner; Ronald W. Hart; Kenneth L. Hastings; A. Wallace Hayes; George R. Hoffmann; John A. Ives; Zbigniew Jaworowski; Thomas E. Johnson; Wayne B. Jonas; Norbert E. Kaminski; John G. Keller; James E. Klaunig; Thomas B. Knudsen; Walter J. Kozumbo; Teresa Lettieri; Shu Zheng Liu; Andre Maisseu; Kenneth I. Maynard; Edward J. Masoro; Roger O. McClellan; Harihara M. Mehendale; Carmel Mothersill; David B. Newlin; Herbert N. Nigg; Frederick W. Oehme; Robert F. Phalen; Martin A. Philbert; Suresh I S Rattan; Jim E. Riviere; Joseph Rodricks; Robert M. Sapolsky; Bobby R. Scott; Colin Seymour; David A. Sinclair; Joan Smith-Sonneborn; Elizabeth T. Snow; Linda Spear; Donald E. Stevenson; Yolene Thomas; Maurice Tubiana; Gary M. Williams; Mark P. Mattson

doi:10.1016/j.taap.2007.02.015

Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework

Edward J. Calabrese, Kenneth A. Bachmann, A. John Bailer, P. Michael Bolger, Jonathan Borak, Lu Cai, Nina Cedergreen, M. George Cherian, Juang-Ching Chiue, Thomas W. Clarkson, Ralph R. Cook, David M. Diamond, David J. Doolittle, Michael A. Dorato, Stephen O. Duke, Ludwig Feinendegen, Donald E. Gardner, Ronald W. Hart, Kenneth L. Hastings, A. Wallace HayesGeorge R. Hoffmann, John A. Ives, Zbigniew Jaworowski, Thomas E. Johnson, Wayne B. Jonas, Norbert E. Kaminski, John G. Keller, James E. Klaunig, Thomas B. Knudsen, Walter J. Kozumbo, Teresa Lettieri, Shu Zheng Liu, Andre Maisseu, Kenneth I. Maynard, Edward J. Masoro, Roger O. McClellan, Harihara M. Mehendale, Carmel Mothersill, David B. Newlin, Herbert N. Nigg, Frederick W. Oehme, Robert F. Phalen, Martin A. Philbert, Suresh I S Rattan, Jim E. Riviere, Joseph Rodricks, Robert M. Sapolsky, Bobby R. Scott, Colin Seymour, David A. Sinclair, Joan Smith-Sonneborn, Elizabeth T. Snow, Linda Spear, Donald E. Stevenson, Yolene Thomas, Maurice Tubiana, Gary M. Williams, Mark P. Mattson

Taipei Medical University

Research output: Contribution to journal › Article › peer-review

646 Citations (Scopus)

Abstract

Many biological subdisciplines that regularly assess dose-response relationships have identified an evolutionarily conserved process in which a low dose of a stressful stimulus activates an adaptive response that increases the resistance of the cell or organism to a moderate to severe level of stress. Due to a lack of frequent interaction among scientists in these many areas, there has emerged a broad range of terms that describe such dose-response relationships. This situation has become problematic because the different terms describe a family of similar biological responses (e.g., adaptive response, preconditioning, hormesis), adversely affecting interdisciplinary communication, and possibly even obscuring generalizable features and central biological concepts. With support from scientists in a broad range of disciplines, this article offers a set of recommendations we believe can achieve greater conceptual harmony in dose-response terminology, as well as better understanding and communication across the broad spectrum of biological disciplines.

Original language	English
Pages (from-to)	122-128
Number of pages	7
Journal	Toxicology and Applied Pharmacology
Volume	222
Issue number	1
DOIs	https://doi.org/10.1016/j.taap.2007.02.015
Publication status	Published - Jul 1 2007

Keywords

Adaptive response
Biphasic
Conditioning
Dose-response
Hormesis
Postconditioning
Preconditioning
Stress response
U-shaped

ASJC Scopus subject areas

Pharmacology
Toxicology

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10.1016/j.taap.2007.02.015

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Calabrese, E. J., Bachmann, K. A., Bailer, A. J., Bolger, P. M., Borak, J., Cai, L., Cedergreen, N., Cherian, M. G., Chiue, J.-C., Clarkson, T. W., Cook, R. R., Diamond, D. M., Doolittle, D. J., Dorato, M. A., Duke, S. O., Feinendegen, L., Gardner, D. E., Hart, R. W., Hastings, K. L., ... Mattson, M. P. (2007). Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework. Toxicology and Applied Pharmacology, 222(1), 122-128. https://doi.org/10.1016/j.taap.2007.02.015

Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework. / Calabrese, Edward J.; Bachmann, Kenneth A.; Bailer, A. John et al.
In: Toxicology and Applied Pharmacology, Vol. 222, No. 1, 01.07.2007, p. 122-128.

Research output: Contribution to journal › Article › peer-review

Calabrese, EJ, Bachmann, KA, Bailer, AJ, Bolger, PM, Borak, J, Cai, L, Cedergreen, N, Cherian, MG, Chiue, J-C, Clarkson, TW, Cook, RR, Diamond, DM, Doolittle, DJ, Dorato, MA, Duke, SO, Feinendegen, L, Gardner, DE, Hart, RW, Hastings, KL, Hayes, AW, Hoffmann, GR, Ives, JA, Jaworowski, Z, Johnson, TE, Jonas, WB, Kaminski, NE, Keller, JG, Klaunig, JE, Knudsen, TB, Kozumbo, WJ, Lettieri, T, Liu, SZ, Maisseu, A, Maynard, KI, Masoro, EJ, McClellan, RO, Mehendale, HM, Mothersill, C, Newlin, DB, Nigg, HN, Oehme, FW, Phalen, RF, Philbert, MA, Rattan, SIS, Riviere, JE, Rodricks, J, Sapolsky, RM, Scott, BR, Seymour, C, Sinclair, DA, Smith-Sonneborn, J, Snow, ET, Spear, L, Stevenson, DE, Thomas, Y, Tubiana, M, Williams, GM & Mattson, MP 2007, 'Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework', Toxicology and Applied Pharmacology, vol. 222, no. 1, pp. 122-128. https://doi.org/10.1016/j.taap.2007.02.015

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abstract = "Many biological subdisciplines that regularly assess dose-response relationships have identified an evolutionarily conserved process in which a low dose of a stressful stimulus activates an adaptive response that increases the resistance of the cell or organism to a moderate to severe level of stress. Due to a lack of frequent interaction among scientists in these many areas, there has emerged a broad range of terms that describe such dose-response relationships. This situation has become problematic because the different terms describe a family of similar biological responses (e.g., adaptive response, preconditioning, hormesis), adversely affecting interdisciplinary communication, and possibly even obscuring generalizable features and central biological concepts. With support from scientists in a broad range of disciplines, this article offers a set of recommendations we believe can achieve greater conceptual harmony in dose-response terminology, as well as better understanding and communication across the broad spectrum of biological disciplines.",

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AU - Bailer, A. John

AU - Bolger, P. Michael

AU - Borak, Jonathan

AU - Cai, Lu

AU - Cedergreen, Nina

AU - Cherian, M. George

AU - Chiue, Juang-Ching

AU - Clarkson, Thomas W.

AU - Cook, Ralph R.

AU - Diamond, David M.

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AU - Knudsen, Thomas B.

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Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework

Abstract

Keywords

ASJC Scopus subject areas

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